{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:39:30Z","timestamp":1783615170196,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["N01-AG-6-2101"],"award-info":[{"award-number":["N01-AG-6-2101"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["N01-AG-6-2103"],"award-info":[{"award-number":["N01-AG-6-2103"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["N01-AG-6-2106"],"award-info":[{"award-number":["N01-AG-6-2106"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["R01-AG028050"],"award-info":[{"award-number":["R01-AG028050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research Grant","doi-asserted-by":"crossref","award":["R01-NR-012459"],"award-info":[{"award-number":["R01-NR-012459"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Program of the National Institutes of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,8]]},"abstract":"\n Objectives<\/jats:title>\n To examine associations between weight change, body composition, risk of mobility disability, and mortality in older adults.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective, longitudinal, population\u2010based cohort.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n The\n H<\/jats:styled-content>\n ealth,\n A<\/jats:styled-content>\n ging, and\n B<\/jats:styled-content>\n ody\n C<\/jats:styled-content>\n omposition\n S<\/jats:styled-content>\n tudy.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Women (n\u00a0=\u00a01,044) and men (n\u00a0=\u00a0931) aged 70 to 79.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Weight and lean and fat mass from dual\u2010energy\n X<\/jats:styled-content>\n \u2010ray absorptiometry measured annually over 5\u00a0years. Weight was defined as stable (n\u00a0=\u00a0664, reference), loss (n\u00a0=\u00a0662), gain (n\u00a0=\u00a0321), or cycling (gain and loss, n\u00a0=\u00a0328) using change of 5% from year to year or from\n Y<\/jats:styled-content>\n ear 1 to 6. Mobility disability (two consecutive reports of difficulty walking one\u2010quarter mile or climbing 10 steps) and mortality were determined for 8\u00a0years after the weight change period. Associations were analyzed using\n C<\/jats:styled-content>\n ox proportional hazards regression adjusted for covariates.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n During follow\u2010up, 313 women and 375 men developed mobility disability, and 322 women and 378 men died. There was no risk of mobility disability or mortality with weight gain. Weight loss (hazard ratio (\n HR<\/jats:styled-content>\n )\u00a0=\u00a01.88, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.40\u20132.53) and weight cycling (\n HR<\/jats:styled-content>\n \u00a0=\u00a01.59, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.11\u20132.29) were associated with mobility disability in women, and weight loss was associated with mobility disability in men (\n HR<\/jats:styled-content>\n \u00a0=\u00a01.30, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.01\u20131.69). Weight loss and weight cycling were associated with mortality risk in women (weight loss:\n HR<\/jats:styled-content>\n \u00a0=\u00a01.47, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.07\u20132.01; weight cycling:\n HR<\/jats:styled-content>\n \u00a0=\u00a01.62, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.15\u20132.30) and in men (weight loss:\n HR<\/jats:styled-content>\n \u00a0=\u00a01.41, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.09\u20131.83; weight cycling:\n HR<\/jats:styled-content>\n \u00a0=\u00a01.50, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.08\u20132.08). Adjustment for lean and fat mass and change in lean and fat mass from Year 1 to 6 attenuated the relationships between weight loss and mobility disability in men and between weight loss and mortality in men and women.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Weight cycling and weight loss predict impending mobility disability and mortality in old age, underscoring the prognostic importance of weight history.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.12954","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T15:37:43Z","timestamp":1405438663000},"page":"1476-1483","source":"Crossref","is-referenced-by-count":89,"title":["Weight Change, Body Composition, and Risk of Mobility Disability and Mortality in Older Adults: A Population\u2010Based Cohort Study"],"prefix":"10.1111","volume":"62","author":[{"given":"Rachel A.","family":"Murphy","sequence":"first","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences Intramural Research Program National Institute on Aging Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushang V.","family":"Patel","sequence":"additional","affiliation":[{"name":"Center for Pain Research on Impact, Measurement and Effectiveness Department of Anesthesiology and Pain Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Sticht Center on Aging Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise K.","family":"Houston","sequence":"additional","affiliation":[{"name":"Sticht Center on Aging Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health Department of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Koster","sequence":"additional","affiliation":[{"name":"CAPHRI School for Public Health and Primary Care Department of Social Medicine Maastricht University Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Simonsick","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch National Institute on Aging Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances A.","family":"Tylvasky","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Health Science Center University of Tennessee Memphis Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy M.","family":"Cawthon","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center Research Institute San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology and Population Sciences Intramural Research Program National Institute on Aging Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Health, Aging, and Body Composition Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2001.49258.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq168"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp050"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.22.2575"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070412"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.03245.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp217"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.006379"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.62"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510380049036"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp007"},{"key":"e_1_2_7_13_1","unstructured":"Weight cycling. 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