{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:17:58Z","timestamp":1762186678742,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T00:00:00Z","timestamp":1411171200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute on Aging NIA","award":["AG023629"],"award-info":[{"award-number":["AG023629"]}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"crossref","award":["HHSN268201200036C","HHSN268200800007C","N01 HC55222","N01HC85079","N01HC85080","N01HC85081","N01HC85082","N01HC85083","N01HC85086","HL080295"],"award-info":[{"award-number":["HHSN268201200036C","HHSN268200800007C","N01 HC55222","N01HC85079","N01HC85080","N01HC85081","N01HC85082","N01HC85083","N01HC85086","HL080295"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"American Heart Association Western States Affiliate","award":["11CRP7210088"],"award-info":[{"award-number":["11CRP7210088"]}]},{"name":"NIA","award":["K01AG039387"],"award-info":[{"award-number":["K01AG039387"]}]},{"name":"University of Pittsburgh Claude D. Pepper Older Americans Independence Center","award":["P30AG024827"],"award-info":[{"award-number":["P30AG024827"]}]},{"name":"CHS All Stars NIA R01","award":["AG023629"],"award-info":[{"award-number":["AG023629"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine the contribution of gradations of subclinical vascular disease (\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      ) to the likelihood of longer survival and to determine what allows some individuals with\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      to live longer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Cardiovascular Health Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals born between June 30, 1918, and June 30, 1921 (N\u00a0=\u00a02,082; aged 70\u201375 at baseline (1992\u201393)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      A\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      index was scored as 0 for no abnormalities, 1 for mild abnormalities, and 2 for severe abnormalities on ankle\u2013arm index, electrocardiogram, and common carotid intima\u2010media thickness measured at baseline. Survival groups were categorized as 80 and younger, 81 to 84, 85 to 89, and 90 and older.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A 1\u2010point lower\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      score was associated with 1.22 greater odds (95% confidence interval\u00a0=\u00a01.14\u20131.31) of longer survival, independent of potential confounders. This association was unchanged after adjustment for intermediate incident cardiovascular events. There was suggestion of an interaction between kidney function, smoking, and C\u2010reactive protein and\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      ; the association between\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      and longer survival appeared to be modestly greater in persons with poor kidney function, inflammation, or a history of smoking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A lower burden of\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      is associated with longer survival, independent of intermediate cardiovascular events. Abstinence from smoking, better kidney function, and lower inflammation may attenuate the effects of higher\n                      <jats:styled-content style=\"fixed-case\">SVD<\/jats:styled-content>\n                      and promote longer survival.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13018","type":"journal-article","created":{"date-parts":[[2014,9,20]],"date-time":"2014-09-20T09:14:31Z","timestamp":1411204471000},"page":"1692-1698","source":"Crossref","is-referenced-by-count":11,"title":["Subclinical Vascular Disease Burden and Longer Survival"],"prefix":"10.1111","volume":"62","author":[{"given":"Michelle C.","family":"Odden","sequence":"first","affiliation":[{"name":"School of Biological and Population Health Sciences Oregon State University Corvallis Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura M.","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice M.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason L.","family":"Sanders","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calvin","family":"Hirsch","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California at Davis Medical Center Sacramento California"},{"name":"Department of Public Health Sciences University of California at Davis Medical Center Sacramento California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"deFilippi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Maryland Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge R.","family":"Kizer","sequence":"additional","affiliation":[{"name":"Department of Medicine Albert Einstein College of Medicine Bronx New York"},{"name":"Department ofEpidemiology and Population Health Albert Einstein College of Medicine Bronx New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Inzitari","sequence":"additional","affiliation":[{"name":"Parc Sanitari Pere Virgili Barcelona Spain"},{"name":"Universitat Aut\u00f2noma de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of 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