{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:29:43Z","timestamp":1780410583638,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T00:00:00Z","timestamp":1412294400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute on Aging (NIA)","award":["R01AG027017"],"award-info":[{"award-number":["R01AG027017"]}]},{"name":"National Institute on Aging (NIA)","award":["P30AG024827"],"award-info":[{"award-number":["P30AG024827"]}]},{"name":"National Institute on Aging (NIA)","award":["T32 AG021885"],"award-info":[{"award-number":["T32 AG021885"]}]},{"name":"National Institute on Aging (NIA)","award":["K07AG033174"],"award-info":[{"award-number":["K07AG033174"]}]},{"name":"National Institute on Aging (NIA)","award":["R01AG028050"],"award-info":[{"award-number":["R01AG028050"]}]},{"name":"Intramural Research program of the National Institutes of Health","award":["N01-AG-6-2101"],"award-info":[{"award-number":["N01-AG-6-2101"]}]},{"name":"Intramural Research program of the National Institutes of Health","award":["N01-AG-6-2103"],"award-info":[{"award-number":["N01-AG-6-2103"]}]},{"name":"Intramural Research program of the National Institutes of Health","award":["N01-AG-6-2106"],"award-info":[{"award-number":["N01-AG-6-2106"]}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research grant","doi-asserted-by":"crossref","award":["R01 NR012459"],"award-info":[{"award-number":["R01 NR012459"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine whether older adults taking nonsteroidal anti\u2010inflammatory drugs (\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s) decreased the underuse of gastroprotective agents over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Before\u2010and\u2010after study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Health, Aging and Body Composition Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Daily users of a\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      (prescription and over the counter (\n                      <jats:styled-content style=\"fixed-case\">OTC<\/jats:styled-content>\n                      )) at visits in 2002\u201303 (preperiod; n\u00a0=\u00a0404) and 2006\u201307 (postperiod; n\u00a0=\u00a0172). The sample had a mean\u00a0\u00b1\u00a0standard deviation age of 78.2\u00a0\u00b1\u00a02.7 at the preperiod visit and 81.9\u00a0\u00b1\u00a02.7 at the postperiod visit. The majority were white and female and had 12 or more years of education.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Underusers were defined as persons taking nonselective\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s who were at risk of peptic ulcer disease (\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      ; because of current warfarin or glucocorticoid use or history of\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      ) and not using a proton pump inhibitor (\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      ) or persons taking cyclooxygenase 2 (\n                      <jats:styled-content style=\"fixed-case\">COX<\/jats:styled-content>\n                      \u20102) selective\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      s and aspirin who were at risk of\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      (having at least one risk factor) and not using a\n                      <jats:styled-content style=\"fixed-case\">PPI<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Daily\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      use decreased from 17.6% to 11.3% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), and gastroprotective agent underuse decreased from 23.5% to 15.1% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.008). Controlling for important covariates, having prescription insurance was somewhat protective against underuse in the preperiod (adjusted odds ratio (\n                      <jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\n                      )\u00a0=\u00a00.78, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a00.46\u20131.34;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.37), but more so and significantly in the postperiod (\n                      <jats:styled-content style=\"fixed-case\">AOR<\/jats:styled-content>\n                      \u00a0=\u00a00.41, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a00.18\u20130.93;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03). Having prescription insurance was more protective in the post\u2010 than in the preperiod (less gastroprotective agent underuse; adjusted ratio of\n                      <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\n                      \u00a0=\u00a00.53, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a00.22\u20131.29;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.16), but this increased protection was not statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In older daily\n                      <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>\n                      users at high risk of\n                      <jats:styled-content style=\"fixed-case\">PUD<\/jats:styled-content>\n                      , having prescription insurance and adequate gastroprotective use was more common in the post\u2010 than in the preperiod.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13066","type":"journal-article","created":{"date-parts":[[2014,10,3]],"date-time":"2014-10-03T22:16:38Z","timestamp":1412374598000},"page":"1923-1927","source":"Crossref","is-referenced-by-count":8,"title":["Gastroprotective Agent Underuse in High\u2010Risk Older Daily Nonsteroidal Anti\u2010Inflammatory Drug Users over Time"],"prefix":"10.1111","volume":"62","author":[{"given":"Zachary A.","family":"Marcum","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine School of Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Hanlon","sequence":"additional","affiliation":[{"name":"Division of Geriatric 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