{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:04:06Z","timestamp":1773965046972,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"crossref","award":["NIH-1K23 RR018929-01A2"],"award-info":[{"award-number":["NIH-1K23 RR018929-01A2"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the epidemiology and outcomes of community\u2010acquired meningitis in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Participants adults in Houston, Texas, with community\u2010acquired meningitis hospitalized between January 1, 2005, and January 1, 2010 (N\u00a0=\u00a0619; n\u00a0=\u00a054, 8.7%, aged \u226565; n\u00a0=\u00a0565 aged &lt;65).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An adverse clinical outcome was defined as a Glasgow Outcome Scale score of 4 or less.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Older adults had higher rates of comorbidities, abnormal neurological and laboratory (serum white blood cell count &gt;12,000\/\n                      <jats:italic>\u03bc<\/jats:italic>\n                      L, and cerebrospinal fluid protein &gt;100\u00a0mg\/dL) findings (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), abnormalities on computed tomography and magnetic resonance imaging of the head (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002), and adverse clinical outcomes (ACOs) (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). The majority of participants (65.8%) had meningitis of unknown etiology. Bacterial meningitis was an infrequent cause of community\u2010acquired meningitis (7.4%). Of the known causes, bacterial meningitis and West Nile virus were more common in older than younger adults; younger participants more frequently had cryptococcal and viral meningitis. On logistic regression, female sex was predictive of a poor outcome in the older participants (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002), whereas abnormal neurological examination (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001), fever (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01), and a cerebrospinal fluid glucose level less than 45\u00a0mg\/dL (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) were significant poor prognostic factors in younger participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most cases of community\u2010acquired meningitis are of unknown origin. Older adults are more likely than younger adults to have bacterial meningitis and West Nile virus infection when a cause can be identified. They also have more neurological abnormalities, laboratory and imaging abnormalities, and adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13110","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T15:25:10Z","timestamp":1415114710000},"page":"2064-2070","source":"Crossref","is-referenced-by-count":38,"title":["Community\u2010Acquired Meningitis in Older Adults: Clinical Features, Etiology, and Prognostic Factors"],"prefix":"10.1111","volume":"62","author":[{"given":"Amy Y.","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of Texas Health Science Center Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge D.","family":"Machicado","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Texas Health Science Center Houston 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