{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:54:22Z","timestamp":1789570462292,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/08\/013\/25942"],"award-info":[{"award-number":["RG\/08\/013\/25942"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,12]]},"abstract":"\n Objectives<\/jats:title>\n \n To examine the independent relationships between fibrin\n D<\/jats:styled-content>\n \u2010dimer, interleukin 6 (\n IL<\/jats:styled-content>\n \u20106),\n C<\/jats:styled-content>\n \u2010reactive protein (\n CRP<\/jats:styled-content>\n ), and fibrinogen and incident mobility limitation and mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n General practice in 24\n B<\/jats:styled-content>\n ritish towns.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Men aged 60 to 79 without prevalent heart failure followed up for an average of 11.5\u00a0years (N\u00a0=\u00a03,925).<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n All\u2010cause mortality (n\u00a0=\u00a01,286) and self\u2010reported mobility disability obtained at examination in 1998 to 2000 and in a postal questionnaire 3 to 5\u00a0years later in 2003.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n High\n D<\/jats:styled-content>\n \u2010dimer (top vs lowest tertile: adjusted odds ratio (\n aOR<\/jats:styled-content>\n )\u00a0=\u00a01.46, 95% confidence interval\u00a0=\u00a01.02\u20132.05) and\n IL<\/jats:styled-content>\n \u20106 (a\n OR<\/jats:styled-content>\n \u00a0=\u00a01.43, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.01\u20132.02) levels (but not\n CRP<\/jats:styled-content>\n or fibrinogen) were associated with greater incident mobility limitation after adjustment for confounders and prevalent disease status. IL\u20106,\n CRP<\/jats:styled-content>\n , fibrinogen, and\n D<\/jats:styled-content>\n \u2010dimer were significantly associated with total mortality after adjustment for confounders. Only\n D<\/jats:styled-content>\n \u2010dimer and\n IL<\/jats:styled-content>\n \u20106 predicted total mortality independent of each other and the other biomarkers. The adjusted hazard ratio (\n aHR<\/jats:styled-content>\n ) was 1.16 (95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.10\u20131.22) for a standard deviation increase in log\n D<\/jats:styled-content>\n \u2010dimer and 1.10 (95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.04\u20131.18) for a standard deviation increase in log\n IL<\/jats:styled-content>\n \u20106.\n D<\/jats:styled-content>\n \u2010dimer was independently related to vascular and nonvascular mortality, and\n IL<\/jats:styled-content>\n \u20106 was independently related to vascular mortality. Risks of mobility limitation and mortality were greatest in those with a combination of high\n D<\/jats:styled-content>\n \u2010dimer and\n IL<\/jats:styled-content>\n \u20106 levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n D<\/jats:styled-content>\n \u2010dimer and\n IL<\/jats:styled-content>\n \u20106 are associated with risk of mobility limitation and mortality in older men without heart failure. The findings suggest that coagulation leads to functional decline and mortality s that inflammation does not explain.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.13133","type":"journal-article","created":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T06:15:30Z","timestamp":1419315330000},"page":"2357-2362","source":"Crossref","is-referenced-by-count":43,"title":["Associations Between Fibrin\n D<\/scp>\n \u2010Dimer, Markers of Inflammation, Incident Self\u2010Reported Mobility Limitation, and All\u2010Cause Mortality in Older Men"],"prefix":"10.1111","volume":"62","author":[{"given":"S. Goya","family":"Wannamethee","sequence":"first","affiliation":[{"name":"Department of Primary Care and Population Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Whincup","sequence":"additional","affiliation":[{"name":"Population Health Research Institute St George's, University of London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Lennon","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olia","family":"Papacosta","sequence":"additional","affiliation":[{"name":"Department of Primary Care and Population Health University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon D.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.11.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03061.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-922485"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.6.802"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1994.tb04733.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324810"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61717-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.14.1799"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61931-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00039-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-012-9706-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52308.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(02)01484-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53510.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50157.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr246"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21429"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr121"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.083410"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn049"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.301174"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034218"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.283.6285.179"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04977.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000016346.14762.71"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03574.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2005.01.007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/22.4.479"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.01.030"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.09.030"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13133","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.13133","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.13133","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.13133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:42:05Z","timestamp":1762188125000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.13133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/jgs.13133"],"URL":"https:\/\/doi.org\/10.1111\/jgs.13133","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}