{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:03:44Z","timestamp":1762189424099,"version":"build-2065373602"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,12,8]],"date-time":"2014-12-08T00:00:00Z","timestamp":1417996800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["N01-AG-6-2101","N01-AG-6-2103","N01-AG-6-2106","1-R01-AG 028050"],"award-info":[{"award-number":["N01-AG-6-2101","N01-AG-6-2103","N01-AG-6-2106","1-R01-AG 028050"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"crossref","award":["R01-NR012459"],"award-info":[{"award-number":["R01-NR012459"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Program of the National Institutes of Health"},{"name":"University of Pittsburgh Claude D. Pepper Older Americans Independence Center","award":["P30-AG024827"],"award-info":[{"award-number":["P30-AG024827"]}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"crossref","award":["1-04-JF-46"],"award-info":[{"award-number":["1-04-JF-46"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the relationship between sensorimotor nerve function and incident mobility disability over 10\u00a0years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study with longitudinal analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      Two\n                      <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\n                      .\n                      <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>\n                      . clinical sites.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Population\u2010based sample of community\u2010dwelling older adults with no mobility disability at 2000\/01 examination (N\u00a0=\u00a01,680; mean age \u00b1\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      76.5\u00a0\u00b1\u00a02.9, body mass index 27.1\u00a0\u00b1\u00a04.6; 50.2% female, 36.6% black, 10.7% with diabetes mellitus).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Motor nerve conduction amplitude (poor &lt;1\n                      <jats:styled-content style=\"fixed-case\">mV<\/jats:styled-content>\n                      ) and velocity (poor &lt;40\u00a0m\/s) were measured on the deep peroneal nerve. Sensory nerve function was measured using 10\u2010 and 1.4\u2010g monofilaments and vibration detection threshold at the toe. Lower extremity symptoms included numbness or tingling and aching or burning pain. Incident mobility disability assessed semiannually over 8.5\u00a0years (interquartile range 4.5\u20139.6\u00a0years) was defined as two consecutive self\u2010reports of a lot of difficulty or inability to walk one\u2010quarter of a mile or climb 10 steps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nerve impairments were detected in 55% of participants, and 30% developed mobility disability. Worse motor amplitude (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a01.29 per\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      , 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.16\u20131.44), vibration detection threshold (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a01.13 per\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      , 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.04\u20131.23), symptoms (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a01.65, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.26\u20132.17), two motor impairments (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a02.10, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.43\u20133.09), two sensory impairments (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a01.91, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.37\u20132.68), and three or more nerve impairments (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a02.33, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.54\u20133.53) predicted incident mobility disability after adjustment. Quadriceps strength mediated relationships between certain nerve impairments and mobility disability, although most remained significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Poor sensorimotor nerve function independently predicted mobility disability. Future work should investigate modifiable risk factors and interventions such as strength training for preventing disability and improving function in older adults with poor nerve function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13152","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:56:38Z","timestamp":1418086598000},"page":"2273-2279","source":"Crossref","is-referenced-by-count":39,"title":["Sensory and Motor Peripheral Nerve Function and Incident Mobility Disability"],"prefix":"10.1111","volume":"62","author":[{"given":"Rachel E.","family":"Ward","sequence":"first","affiliation":[{"name":"Spaulding Rehabilitation Hospital Cambridge Massachusetts"},{"name":"School of Public Health Boston University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Boudreau","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Caserotti","sequence":"additional","affiliation":[{"name":"Institute of Sports Science and Clinical Biomechanics University of Southern Denmark Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara B.","family":"Harris","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Biometry, and Demography National Institute on Aging National Institutes of Health Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sasa","family":"Zivkovic","sequence":"additional","affiliation":[{"name":"Department of Neurology School of Medicine University of Pittsburgh Pittsburgh Pennsylvania"},{"name":"Veterans Affairs Pittsburgh Health Care System Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bret H.","family":"Goodpaster","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Satterfield","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine University of Tennessee Memphis Tennessee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Division of Gerontology and Geriatric Medicine Department of Internal Medicine School of Medicine, Wake Forest Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann V.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics University of California at San Francisco San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron I.","family":"Vinik","sequence":"additional","affiliation":[{"name":"Department of Neurobiology Eastern Virginia Medical School Norfolk Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor M.","family":"Simonsick","sequence":"additional","affiliation":[{"name":"Translational Gerontology Branch National Institute on Aging National Institutes of Health Baltimore Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsa S.","family":"Strotmeyer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health, University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Health, Aging and Body Composition Study","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0433"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.4.678"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000260606.36443.29"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.7.1591"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.23.11.1642"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02487.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.4.M221"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0838.2003.00298.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr158"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/60.3.324"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2004.01.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111152298"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.07.027"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-6632(91)90003-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-S067"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21263"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.140.1.41"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03998.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-199301000-00011"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2004.52575.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51105.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(02)50079-9"},{"key":"e_1_2_6_24_1","unstructured":"National Institute of Neurological Disorders and Stroke.Peripheral neuropathy fact sheet.2012; Available athttp:\/\/www.ninds.nih.gov\/disorders\/peripheralneuropathy\/detail_peripheralneuropathy.htmAccessed February 13 2013."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.06.009"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199505010-00004"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-005-0126-7"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160402"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.5.1011S"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1979.46.3.451"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/113.5.1563"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90245.2008"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.12.3257"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2008.03.011"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.13152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:42:14Z","timestamp":1762188134000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.13152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["10.1111\/jgs.13152"],"URL":"https:\/\/doi.org\/10.1111\/jgs.13152","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"type":"print","value":"0002-8614"},{"type":"electronic","value":"1532-5415"}],"subject":[],"published":{"date-parts":[[2014,12]]}}}