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Difficulty performing activities of daily living and instrumental activities of daily living was assessed at baseline and annually for the next 5\u00a0years. Covariates included demographic characteristics, comorbid conditions, cognitive function, social support, and health behaviors. Five years later, 658 participants returned for follow\u2010up assessments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher baseline depressive symptoms predicted greater risk of functional decline over 5\u00a0years, whereas higher baseline exercise capacity was associated with lower risk of functional decline. In 658 participants who returned for follow\u2010up, 5\u2010year changes in depressive symptoms and exercise capacity were associated with 5\u2010year changes in functional status. Angina pectoris frequency and\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      were not associated with functional decline or change in functional status, after adjusting for covariates and other predictors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In older adults with coronary heart disease, depressive symptoms and lower exercise capacity predicted functional decline over 5\u00a0years. In contrast, other traditional measures of\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      severity (\n                      <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>\n                      and angina pectoris) were not independently predictive of subsequent functional status. These findings suggest that efforts to ameliorate depressive symptoms may be as important as treating\n                      <jats:styled-content style=\"fixed-case\">CVD<\/jats:styled-content>\n                      severity to enhance functional status.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13188","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T05:13:02Z","timestamp":1420002782000},"page":"8-15","source":"Crossref","is-referenced-by-count":43,"title":["Depressive Symptoms, Cardiovascular Disease Severity, and Functional Status in Older Adults with Coronary Heart Disease: The Heart and Soul Study"],"prefix":"10.1111","volume":"63","author":[{"given":"Nancy L.","family":"Sin","sequence":"first","affiliation":[{"name":"Department of Medicine University of California San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of California San Francisco California"},{"name":"Department of Neurology University of California San Francisco California"},{"name":"Department of Epidemiology and Biostatistics University of California San Francisco California"},{"name":"Veterans Affairs Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Whooley","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco California"},{"name":"Department of Epidemiology and Biostatistics University of California San Francisco California"},{"name":"Veterans Affairs Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31828124ad"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.02.014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.15.5.332"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.07.013"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1985.00360090110017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1996.tb04071.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02723.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50259.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53202.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01334-1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2008.10.022"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1999.tb02995.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200003000-00011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2000.106600"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(97)00167-8"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01174-7"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.059451"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515111430928"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.2.215"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2008.711"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.960302"},{"key":"e_1_2_6_24_1","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for quantitation of the left ventricle by two\u2010dimensional echocardiography. 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