{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T08:56:26Z","timestamp":1777712186838,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,30]],"date-time":"2015-01-30T00:00:00Z","timestamp":1422576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["K23AT004251"],"award-info":[{"award-number":["K23AT004251"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["U01AG22376"],"award-info":[{"award-number":["U01AG22376"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["T32AG19134"],"award-info":[{"award-number":["T32AG19134"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"crossref","award":["K07AG043587"],"award-info":[{"award-number":["K07AG043587"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"crossref","award":["3U01AG022376"],"award-info":[{"award-number":["3U01AG022376"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung and Blood Institute","doi-asserted-by":"crossref","award":["HL075451"],"award-info":[{"award-number":["HL075451"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Intramural Research Program"},{"name":"Florida Claude D. Pepper Older Americans Independence Center","award":["P30AG028740"],"award-info":[{"award-number":["P30AG028740"]}]},{"name":"Yale Claude D. Pepper Older Americans Independence Center","award":["P30AG21342"],"award-info":[{"award-number":["P30AG21342"]}]},{"name":"Thomas H. Maren Foundation"},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes, Digestive, and Kidney Disease","doi-asserted-by":"crossref","award":["DK087126"],"award-info":[{"award-number":["DK087126"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Claude D. Pepper Older Americans Independence Centers at the University of Florida","award":["1P30AG028740"],"award-info":[{"award-number":["1P30AG028740"]}]},{"DOI":"10.13039\/100008090","name":"Tufts University","doi-asserted-by":"crossref","award":["1P30AG031679"],"award-info":[{"award-number":["1P30AG031679"]}],"id":[{"id":"10.13039\/100008090","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"crossref","award":["P30AG024827"],"award-info":[{"award-number":["P30AG024827"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005326","name":"Yale University","doi-asserted-by":"crossref","award":["P30AG021342"],"award-info":[{"award-number":["P30AG021342"]}],"id":[{"id":"10.13039\/100005326","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH\/NCRR CTSA at Stanford University","award":["UL1RR025744"],"award-info":[{"award-number":["UL1RR025744"]}]},{"DOI":"10.13039\/100000738","name":"Department of Veterans Affairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"crossref","award":["58-1950-7-707"],"award-info":[{"award-number":["58-1950-7-707"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the prevalence of metabolic syndrome (MetS) and its association with physical capacity, disability, and self\u2010rated health in older adults at high risk of mobility disability, including those with and without diabetes mellitus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      Lifestyle Interventions and Independence for Elders (\n                      <jats:styled-content style=\"fixed-case\">LIFE<\/jats:styled-content>\n                      ) Study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Community\u2010dwelling sedentary adults aged 70 to 89 at high risk of mobility disability (Short Physical Performance Battery (\n                      <jats:styled-content style=\"fixed-case\">SPPB<\/jats:styled-content>\n                      ) score \u22649; mean 7.4\u00a0\u00b1\u00a01.6) (N\u00a0=\u00a01,535).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Metabolic syndrome was defined according to the 2009 multiagency harmonized criteria; outcomes were physical capacity (400\u2010m walk time, grip strength,\n                      <jats:styled-content style=\"fixed-case\">SPPB<\/jats:styled-content>\n                      score), disability (composite 19\u2010item score), and self\u2010rated health (5\u2010point scale ranging from excellent to poor).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of MetS was 49.8% in the overall sample (83.2% of those with diabetes mellitus, 38.1% of those without). MetS was associated with stronger grip strength (mean difference (\u0394)\u00a0=\u00a01.2\u00a0kg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.01) in the overall sample and in participants without diabetes mellitus and with poorer self\u2010rated health (\u0394\u00a0=\u00a00.1\u00a0kg,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) in the overall sample only. No significant differences were found in 400\u2010m walk time,\n                      <jats:styled-content style=\"fixed-case\">SPPB<\/jats:styled-content>\n                      score, or disability score between participants with and without MetS, in the overall sample or diabetes mellitus subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Metabolic dysfunction is highly prevalent in older adults at risk of mobility disability, yet consistent associations were not observed between MetS and walking speed, lower extremity function, or self\u2010reported disability after adjusting for known and potential confounders. Longitudinal studies are needed to investigate whether MetS accelerates declines in functional status in high\u2010risk older adults and to inform clinical and public health interventions aimed at preventing or delaying disability in this group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13205","type":"journal-article","created":{"date-parts":[[2015,1,31]],"date-time":"2015-01-31T00:14:57Z","timestamp":1422663297000},"page":"222-232","source":"Crossref","is-referenced-by-count":38,"title":["Prevalence of Metabolic Syndrome and Its Association with Physical Capacity, Disability, and Self\u2010Rated Health in Lifestyle Interventions and Independence for Elders Study Participants"],"prefix":"10.1111","volume":"63","author":[{"given":"Anda","family":"Botoseneanu","sequence":"first","affiliation":[{"name":"Department of Health Policy Studies University of Michigan Ann Arbor, Dearborn Michigan"},{"name":"Institute of Gerontology University of Michigan Ann Arbor, Dearborn Michigan"},{"name":"Division of Geriatrics Department of Internal Medicine School of Medicine Yale University New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter T.","family":"Ambrosius","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Beavers","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"de Rekeneire","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Department of Internal Medicine School of Medicine Yale University New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Anton","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research Institute on Aging University of Florida Gainesville Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Church","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Louisiana State University Baton Rouge Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara C.","family":"Folta","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy Tufts University Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bret H.","family":"Goodpaster","sequence":"additional","affiliation":[{"name":"Metabolic Disease Program Sanford | Burnham Medical Research Institute Orlando Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy Stanford University Stanford California"},{"name":"Department of Medicine Stanford Prevention Research Center School of Medicine Stanford University Stanford California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara J.","family":"Nicklas","sequence":"additional","affiliation":[{"name":"J. Paul Sticht Center on Aging School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Spring","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuewen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Exercise Science University of South Carolina Columbia South Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Department of Internal Medicine School of Medicine Yale University New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the LIFE Study Groups","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0579.2003.00207.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.11.M691"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.558"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.4.M221"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/50A.4.M177"},{"key":"e_1_2_6_8_1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/gerona\/61.11.1157","article-title":"Effects of a physical activity intervention on measures of physical performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE\u2010P) study","volume":"61","author":"Pahor M","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2010.00078.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0879"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04105.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00607.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03518.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls213"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcm095"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2200"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/50B.6.S344"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.9.874"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2001.0840"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.10.M609"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(00)00249-5"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0737-1209.2005.220607.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr123"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200107000-00010"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2018"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00962.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.3.M168"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00436-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2008.00446.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2007.04.031"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318276fbcb"},{"key":"e_1_2_6_34_1","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) Examination","volume":"48","author":"Teng E","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt101"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-6-282"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-9-49"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afm105"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2012.00647.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.7.777"},{"key":"e_1_2_6_41_1","first-page":"1","article-title":"Prevalence of metabolic syndrome among adults 20\u00a0years of age and over, by sex, age, race and ethnicity, and body mass index: United States","volume":"13","author":"Ervin RB","year":"2009","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi007"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2006.07.002"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2010.0101"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.08.005"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01068.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-012-0025-0"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.13205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:05:17Z","timestamp":1762167917000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.13205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,30]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/jgs.13205"],"URL":"https:\/\/doi.org\/10.1111\/jgs.13205","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,30]]}}}