{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:20:01Z","timestamp":1762168801108,"version":"build-2065373602"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T00:00:00Z","timestamp":1424131200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["01ET1005A"],"award-info":[{"award-number":["01ET1005A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To present detailed adverse event (\n                      <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                      ) data from a randomized controlled trial (\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      ) of a home\u2010based exercise program delivered to an elderly high\u2010risk population by an exercise therapist after medical clearance from a general practitioner (\n                      <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>General practitioner practices and participant homes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Community\u2010dwelling, chronically ill, mobility\u2010limited individuals aged 70 and older (mean 80\u00a0\u00b1\u00a05) participating in a\n                      <jats:styled-content style=\"fixed-case\">RCT<\/jats:styled-content>\n                      of an exercise program (\n                      <jats:styled-content style=\"fixed-case\">HOME<\/jats:styled-content>\n                      fit;\n                      <jats:styled-content style=\"fixed-case\">ISRCTN<\/jats:styled-content>\n                      17727272) (N\u00a0=\u00a0209; n\u00a0=\u00a0106 experimental, n\u00a0=\u00a0103 control; 74% female).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>\n                      A 12\u2010week multidimensional home\u2010based exercise program (experimental) versus baseline physical activity counseling (control). An exercise therapist delivered both interventions to participants during counseling sessions at the\n                      <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>\n                      's practice and on the telephone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Adverse events were documented at least at every counseling session and assessed by the\n                      <jats:styled-content style=\"fixed-case\">GP<\/jats:styled-content>\n                      and an\n                      <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                      manager.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred fifty\u2010one\n                      <jats:styled-content style=\"fixed-case\">AE<\/jats:styled-content>\n                      s were reported in 47% (n\u00a0=\u00a099) of all participants. Twenty\u2010one (14%) events were classified as serious. In six events (4%; n\u00a0=\u00a04 experimental, n\u00a0=\u00a02 control), participation in the study had to be discontinued immediately. In 25 events (17%; n\u00a0=\u00a09 experimental, n\u00a0=\u00a016 control), the intervention had to be suspended. The intervention was determined to have caused two events (both nonserious and in the experimental group).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Even though the program appears to be safe, high morbidity unrelated to exercise can constitute a critical challenge for sustained exercise participation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13253","type":"journal-article","created":{"date-parts":[[2015,2,17]],"date-time":"2015-02-17T01:50:45Z","timestamp":1424137845000},"page":"258-269","source":"Crossref","is-referenced-by-count":10,"title":["Adverse Events in Mobility\u2010Limited and Chronically Ill Elderly Adults Participating in an Exercise Intervention Study Supported by General Practitioner 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