{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:10:29Z","timestamp":1793275829527,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"French Ministry of Health","award":["PHRC 02-006-01"],"award-info":[{"award-number":["PHRC 02-006-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine whether living alone predicted hospitalizations, nursing home admission, weight loss, and death in individuals with mild to moderate Alzheimer's disease (\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      ) over 2\u00a0years of follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Data are from the Plan de Soin et d'Aide dans la maladie d'Alzheimer study, a 24\u2010month trial with a cluster randomization of memory clinics in two arms: a multidomain intervention and usual care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Memory clinics in France (N\u00a0=\u00a050).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Community\u2010dwelling individuals with\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      with a Mini\u2010Mental State Examination score between 12 and 26 and an identified caregiver.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>A neurogeriatric evaluation was conducted twice a year in the intervention group and annually in the control group. Hospitalizations, nursing home admission, weight loss, and death occurring during the past year were recorded. Information on sociodemographic characteristics, clinical conditions, therapy, and physical and cognitive status was recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At inclusion, 348 (30.8%) of the 1,131 participants lived alone. Living alone did not increase the risk of mortality or weight loss in individuals with mild to moderate\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      , but significant associations with risk of hospitalization (hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      )\u00a0=\u00a01.33, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a01.01\u20131.74) and institutionalization (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a02.53, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a01.84\u20133.47) were reported. A protective effect of physical function on institutionalization and mortality was found.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results might support clinicians in making decisions about institutionalization of individuals with\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      living alone or improving home health care, such as increasing screening and managing functional impairment in this complex population.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13347","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T12:05:13Z","timestamp":1429531513000},"page":"651-658","source":"Crossref","is-referenced-by-count":24,"title":["Living Alone with Alzheimer's Disease and the Risk of Adverse Outcomes: Results from the Plan de Soin et d'Aide dans la maladie d'Alzheimer Study"],"prefix":"10.1111","volume":"63","author":[{"given":"Maria","family":"Soto","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine G\u00e9rontop\u00f4le Centre Hospitalier Universitaire ToulouseToulouse University Hospital Toulouse France"},{"name":"Inserm UMR 1027 Toulouse France"},{"name":"Universit\u00e9 Toulouse III Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Andrieu","sequence":"additional","affiliation":[{"name":"Inserm UMR 1027 Toulouse France"},{"name":"Universit\u00e9 Toulouse III Toulouse France"},{"name":"Department of Epidemiology and Public Health G\u00e9rontop\u00f4le Centre Hospitalier UniversitaireToulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Gares","sequence":"additional","affiliation":[{"name":"Inserm UMR 1027 Toulouse France"},{"name":"Universit\u00e9 Toulouse III Toulouse France"},{"name":"Department of Epidemiology and Public Health G\u00e9rontop\u00f4le Centre Hospitalier UniversitaireToulouse University Hospital Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Cesari","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine G\u00e9rontop\u00f4le Centre Hospitalier Universitaire ToulouseToulouse University Hospital Toulouse France"},{"name":"Inserm UMR 1027 Toulouse France"},{"name":"Universit\u00e9 Toulouse III Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Gillette\u2010Guyonnet","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine G\u00e9rontop\u00f4le Centre Hospitalier Universitaire ToulouseToulouse University Hospital Toulouse France"},{"name":"Inserm UMR 1027 Toulouse France"},{"name":"Universit\u00e9 Toulouse III Toulouse 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