{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:31:57Z","timestamp":1791945117042,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2015,6]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine the association between hyperhomocysteinemia and cognitive function, taking into account the effect of B group vitamin (\n BGV<\/jats:styled-content>\n ) deficiency.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Memory Clinic, S. Anna University Hospital, Ferrara, Italy.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Elderly individuals (\u226565) (N\u00a0=\u00a0318; 44 normal cognition, 127 with cognitive impairment, 147 with dementia) divided into four groups according to plasma homocysteine (high vs normal) and\n BGV<\/jats:styled-content>\n (normal vs deficit) levels.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Cognitive, clinical, biochemical, functional, and neuroimaging parameters were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Hyperhomocysteinemia (>15\u00a0\n \u03bc<\/jats:italic>\n mol\/L) was associated with a higher prevalence of cognitive and functional impairment and dementia (odds ratio (\n OR<\/jats:styled-content>\n )\u00a0=\u00a01.98, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.13\u20133.48), independent of\n BGV<\/jats:styled-content>\n status and other confounders. Participants with hyperhomocysteinemia with normal\n BGV<\/jats:styled-content>\n status had the worst functional status and the highest prevalence of dementia (high homocysteine\/normal\n BGV<\/jats:styled-content>\n vs normal homocysteine\/normal\n BGV<\/jats:styled-content>\n :\n OR<\/jats:styled-content>\n \u00a0=\u00a03.20, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.65\u20136.21). Homocysteine levels were correlated negatively with folate and vitamin B12 levels and glomerular filtration rate and positively with free thyroxine and uric acid levels (model coefficient of determination\u00a0=\u00a00.43).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Hyperhomocysteinemia was associated with worse cognitive and functional status and dementia independently of\n BGV<\/jats:styled-content>\n levels. Approximately half of participants with hyperhomocysteinemia had normal\n BGV<\/jats:styled-content>\n levels, suggesting that other unmeasured factors might be associated with high homocysteine levels.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.13431","type":"journal-article","created":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T06:41:33Z","timestamp":1433140893000},"page":"1158-1163","source":"Crossref","is-referenced-by-count":23,"title":["Cognitive Status According to Homocysteine and B\u2010Group Vitamins in Elderly Adults"],"prefix":"10.1111","volume":"63","author":[{"given":"Francesco","family":"Bonetti","sequence":"first","affiliation":[{"name":"Department of Medical Sciences University of Ferrara Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Brombo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences University of Ferrara Ferrara 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