{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:35:46Z","timestamp":1791387346499,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T00:00:00Z","timestamp":1440633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81270865"],"award-info":[{"award-number":["81270865"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81272426"],"award-info":[{"award-number":["81272426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To analyze and summarize the clinical characteristics, surgical outcomes, and prognosis of elderly adults with pituitary adenomas (\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      s).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Tongji Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Individuals who underwent transsphenoidal surgery for\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      s between 2009 and 2012 (N\u00a0=\u00a01,104).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Participants were divided into two age groups (\u226565 and &lt;65), and their clinical characteristics, surgical complications, surgical outcomes, and follow\u2010up data were analyzed and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The older group had longer duration of symptoms. The most common symptom were mass effects (98.4%) in the older group and hormone\u2010secreting effects (55.2%) in the younger group. The incidence of pituitary apoplexy (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03), incidentaloma (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03) and misdiagnosis at first visit (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) were higher in the older group. Nonfunctioning\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      s (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      &lt;\u00a0.001) and giant adenomas (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.04) were more common in the elderly group than in the younger group. There were no significant differences in the incidence of postoperative diabetes insipidus, cerebrospinal fluid (\n                      <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                      ) leak, regrowth, visual outcome, or permanent hypopituitarism between the groups (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). The incidence of severe systemic complications was greater in the older group (3\/69 vs 3\/1,035, relative risk\u00a0=\u00a015.00, 95% confidence interval\u00a0=\u00a03.08\u201372.94,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.004), and all three cases in the older group occurred after emergency surgery. The incidence of hypopituitarism before surgery and 3\u00a0days after surgery was higher in the elderly group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). Older participants tended to have more difficulty recovering from preoperative hypopituitarism (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Avoiding misdiagnosis and emergency surgery is critical for frail elderly adults with multiple comorbidities. With early active management, sufficient preoperative preparation, and multidisciplinary collaboration, the long\u2010term outcomes and prognosis of elderly adults with\n                      <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>\n                      s are comparable with those of younger adults.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13590","type":"journal-article","created":{"date-parts":[[2015,8,27]],"date-time":"2015-08-27T09:16:34Z","timestamp":1440666994000},"page":"1924-1930","source":"Crossref","is-referenced-by-count":44,"title":["Comparison of Pituitary Adenomas in Elderly and Younger Adults: Clinical Characteristics, Surgical Outcomes, and Prognosis"],"prefix":"10.1111","volume":"63","author":[{"given":"Junfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 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