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<jats:p>Community.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals with available data on three or more of five microvascular abnormalities (brain, retina, kidney) and three or more of six macrovascular abnormalities (brain, carotid artery, heart, peripheral artery) (N\u00a0=\u00a02,452; mean age 79.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Standardized composite scores derived from three cognitive tests (Modified Mini\u2010Mental State Examination, Digit\u2010Symbol Substitution Test, Trail\u2010Making Test (\n                      <jats:styled-content style=\"fixed-case\">TMT<\/jats:styled-content>\n                      )) and three physical tests (gait speed, grip strength, 5\u2010time sit to stand)\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants with high microvascular and macrovascular burden had worse cognitive (mean score difference\u00a0=\u00a0\u22120.30, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a0\u22120.37 to \u22120.24) and physical (mean score difference\u00a0=\u00a0\u22120.32, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a0\u22120.38 to \u22120.26) function than those with low microvascular and macrovascular burden. Individuals with high microvascular burden alone had similarly lower scores than those with high macrovascular burden alone (cognitive function: \u22120.16, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a0\u22120.24 to \u22120.08 vs \u22120.13, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a0\u22120.20 to \u22120.06; physical function: \u22120.15, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a0\u22120.22 to \u22120.08 vs \u22120.12, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a0\u22120.18 to \u22120.06). Psychomotor speed and working memory, assessed using the\n                      <jats:styled-content style=\"fixed-case\">TMT<\/jats:styled-content>\n                      , were only impaired in the presence of high microvascular burden. Of the 11 vascular abnormalities considered, white matter hyperintensity, cystatin C\u2013based glomerular filtration rate, large brain infarct, and ankle\u2013arm index were independently associated with cognitive and physical function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Microvascular and macrovascular abnormalities assessed using noninvasive tests of the brain, kidney, and peripheral artery were independently associated with poor cognitive and physical function in older adults. Future research should evaluate the usefulness of these tests in prognostication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.13594","type":"journal-article","created":{"date-parts":[[2015,9,4]],"date-time":"2015-09-04T03:50:54Z","timestamp":1441338654000},"page":"1886-1893","source":"Crossref","is-referenced-by-count":24,"title":["Microvascular and Macrovascular Abnormalities and Cognitive and Physical Function in Older Adults: Cardiovascular Health Study"],"prefix":"10.1111","volume":"63","author":[{"given":"Dae Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Gerontology Beth Israel Deaconess Medical Center Boston Massachusetts"},{"name":"Institute for Aging Research Hebrew Senior Life Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine","family":"Grodstein","sequence":"additional","affiliation":[{"name":"Channing Division of Network Medicine Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo H. 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