{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:45:57Z","timestamp":1790484357187,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T00:00:00Z","timestamp":1443484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2015,10]]},"abstract":"\n Objectives<\/jats:title>\n \n To measure the effect of proton pump inhibitors (\n PPI<\/jats:styled-content>\n s), with and without concurrent bisphosphonates, on parathyroid hormone (\n PTH<\/jats:styled-content>\n ), vitamin D, and calcium.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Retrospective chart review of individuals 60 years and older. Subjects with reduced renal function (creatinine >1.3 mg\/\n dL<\/jats:styled-content>\n ) and low vitamin D (<30 ng\/\n mL<\/jats:styled-content>\n ) were excluded.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Academic geriatric outpatient center in southern midwest.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Individuals aged 60 and older with concurrent calcium,\n PTH<\/jats:styled-content>\n , vitamin D, and creatinine laboratory measurements (\n N<\/jats:italic>\n = 80) meeting labeled criteria.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Serum calcium,\n PTH<\/jats:styled-content>\n , vitamin D, and creatinine.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Chronic\n PPI<\/jats:styled-content>\n exposure was associated with statistically significantly higher\n PTH<\/jats:styled-content>\n (65.5 vs 30.3 pg\/\n mL<\/jats:styled-content>\n ,\n P<\/jats:italic>\n < .001; normal range 10\u201355 pg\/\n mL<\/jats:styled-content>\n ) and lower calcium (9.1 vs 9.4 mg\/\n dL<\/jats:styled-content>\n ,\n P<\/jats:italic>\n = .02; normal range 8.5\u201310.5 mg\/\n dL<\/jats:styled-content>\n ) than no\n PPI<\/jats:styled-content>\n exposure. Chronic\n PPI<\/jats:styled-content>\n exposure with concurrent\n BP<\/jats:styled-content>\n therapy was associated with statistically significantly higher\n PTH<\/jats:styled-content>\n (65.2 vs 43.4 pg\/\n mL<\/jats:styled-content>\n ,\n P<\/jats:italic>\n = .05) and lower calcium (9.2 vs 9.6 mg\/\n dL<\/jats:styled-content>\n ,\n P<\/jats:italic>\n = .04) than\n BP<\/jats:styled-content>\n therapy only.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Based on the present study, chronic\n PPI<\/jats:styled-content>\n exposure in elderly adults is associated with mild hyperparathyroidism regardless of concurrent oral\n BP<\/jats:styled-content>\n administration.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.13661","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T07:17:33Z","timestamp":1443511053000},"page":"2070-2073","source":"Crossref","is-referenced-by-count":43,"title":["Hyperparathyroidism Associated with Long\u2010Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults"],"prefix":"10.1111","volume":"63","author":[{"given":"Andrew M.","family":"Hinson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Arkansas for Medical Sciences Little Rock Arkansas"},{"name":"Department of Geriatrics University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bekka M.","family":"Wilkerson","sequence":"additional","affiliation":[{"name":"Department of Geriatrics University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Rothman\u2010Fitts","sequence":"additional","affiliation":[{"name":"Department of Geriatrics University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann T.","family":"Riggs","sequence":"additional","affiliation":[{"name":"Department of Geriatrics University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Brendan C.","family":"Stack","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald L.","family":"Bodenner","sequence":"additional","affiliation":[{"name":"Department of Geriatrics University of Arkansas for Medical Sciences Little Rock Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"FDA Drug Safety Communication.Possible increased risk of fractures of the hip wrist and spine with the use of proton pump inhibitors. US Department of Health and Human Services [on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm213206.htmAccessed November 23 2014."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2947"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833ea9d9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2010.11.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-014-0030-y"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-006-0021-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.071330"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.11.014"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/archinternmed.2010.94","article-title":"Proton pump inhibitor use, hip fracture, and change in bone mineral density in postmenopausal women","volume":"170","author":"Gray SL","year":"2010","journal-title":"Arch Intern Med"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.02.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12478"},{"key":"e_1_2_7_13_1","volume-title":"Introduction to Probability and Statistics","author":"Mendenhall W","year":"2013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.108"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-013-2335-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-008-9170-1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2011.272"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01352010"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2009.06.011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.1990.tb00457.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409092460"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.10.024"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/452737"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.07.012"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(91)90238-4"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1593"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.20"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0722-9"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13661","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.13661","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.13661","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:25:18Z","timestamp":1762172718000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.13661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,29]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/jgs.13661"],"URL":"https:\/\/doi.org\/10.1111\/jgs.13661","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,29]]}}}