{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:21:44Z","timestamp":1789694504696,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 AG 041660"],"award-info":[{"award-number":["R21 AG 041660"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1 AR050023"],"award-info":[{"award-number":["RO1 AR050023"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000063","name":"Office of Dietary Supplements","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine the dose\u2010response relationship between 25\u2010hydroxyvitamin D (25(\n OH<\/jats:styled-content>\n )D) and supplemental vitamin D\n 3<\/jats:sub>\n in elderly nursing home residents.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Randomized double\u2010blind investigation.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Nursing home.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Of 81 women (n\u00a0=\u00a051) and men (n\u00a0= 30) (mean age 87.4\u00a0\u00b1\u00a08) enrolled, 72 completed the study.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n \n Sixteen weeks of oral vitamin D\n 3<\/jats:sub>\n at 800, 2,000, or 4,000\u00a0\n IU<\/jats:styled-content>\n \/d or 50,000\u00a0\n IU<\/jats:styled-content>\n \/wk.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n The main outcome was 25(\n OH<\/jats:styled-content>\n )D concentrations (tandem mass spectrometry) after 16 weeks. Free 25(\n OH<\/jats:styled-content>\n )D and intact parathyroid hormone (\n iPTH<\/jats:styled-content>\n ) were also analyzed. Safety monitoring of calcium and estimated glomerular filtration rate was performed, and adherence and clinical status were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n 25(\n OH<\/jats:styled-content>\n )D concentrations increased with dose (\n P<\/jats:italic>\n \u00a0<\u00a0.001) and were higher with 50,000\u00a0\n IU<\/jats:styled-content>\n \/wk (\n P<\/jats:italic>\n \u00a0<\u00a0.001) than other doses and with 4,000\u00a0\n IU<\/jats:styled-content>\n \/d than 800 or 2,000\u00a0\n IU<\/jats:styled-content>\n \/d, but 800\u00a0\n IU<\/jats:styled-content>\n and 2,000\u00a0\n IU<\/jats:styled-content>\n \/d did not differ. One subject receiving 800\u00a0\n IU<\/jats:styled-content>\n \/d had concentrations less than 20\u00a0ng\/\n mL<\/jats:styled-content>\n . All subjects receiving more than 2000\u00a0\n IU<\/jats:styled-content>\n \/d had concentrations of 20\u00a0ng\/\n mL<\/jats:styled-content>\n and greater. Free 25(\n OH<\/jats:styled-content>\n )D concentrations rose with total 25(OH) vitamin D. Total and free 25(\n OH<\/jats:styled-content>\n )D were related to calcium concentrations; only free 25(\n OH<\/jats:styled-content>\n )D was related to\n iPTH<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n 25(\n OH<\/jats:styled-content>\n )D increased linearly with 800 to 4,000\u00a0\n IU<\/jats:styled-content>\n \/d and 50,000\u00a0\n IU<\/jats:styled-content>\n \/wk of vitamin D\n 3<\/jats:sub>\n , without a ceiling effect. Data suggest that some elderly adults will require more than 800\n IU<\/jats:styled-content>\n \/d of vitamin D\n 3<\/jats:sub>\n to ensure adequate vitamin D levels. Changes in 25(\n OH<\/jats:styled-content>\n )D with vitamin D\n 3<\/jats:sub>\n were related to starting concentrations (greatest with the lowest concentrations and unchanged with 800 and 2,000\n IU<\/jats:styled-content>\n \/d if 20\u201340\u00a0ng\/\n mL<\/jats:styled-content>\n ). Relationships between serum calcium and\n iPTH<\/jats:styled-content>\n and free 25(\n OH<\/jats:styled-content>\n )D suggest the potential for free 25(\n OH<\/jats:styled-content>\n )D in defining optimal 25(\n OH<\/jats:styled-content>\n )D concentrations.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.13774","type":"journal-article","created":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T04:22:30Z","timestamp":1453177350000},"page":"65-72","source":"Crossref","is-referenced-by-count":49,"title":["Response of Vitamin D Concentration to Vitamin D\n 3<\/sub>\n Administration in Older Adults without Sun Exposure: A Randomized Double\u2010Blind Trial"],"prefix":"10.1111","volume":"64","author":[{"given":"Janice B.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Jewish Home of San Francisco San Francisco California"},{"name":"Department of Medicine University of California at San Francisco San Francisco California"},{"name":"Department of Bioengineering and 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