{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T20:53:48Z","timestamp":1784062428463,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,19]],"date-time":"2016-01-19T00:00:00Z","timestamp":1453161600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG025667"],"award-info":[{"award-number":["AG025667"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine whether 12\u00a0months of aerobic training (\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      ) moderated the relationship between change in mobility and change in basal ganglia volume than balance and toning (\n                      <jats:styled-content style=\"fixed-case\">BAT<\/jats:styled-content>\n                      ) exercises in older adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Secondary analysis of a randomized controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Champaign\u2010Urbana, Illinois.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Community\u2010dwelling older adults (N\u00a0=\u00a0101; mean age 66.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>\n                      Twelve\u2010month exercise trial with two groups:\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BAT<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Mobility was assessed using the Timed Up and Go test. Basal ganglia (putamen, caudate nucleus, pallidum) was segmented from T1\u2010weighted magnetic resonance images using the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Software Library Integrated Registration and Segmentation Tool. Measurements were obtained at baseline and trial completion. Hierarchical multiple regression was conducted to examine whether exercise mode moderates the relationship between change in mobility and change in basal ganglia volume over 12\u00a0months. Age, sex, and education were included as covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Exercise significantly moderated the relationship between change in mobility and change in left putamen volume. Specifically, for the\n                      <jats:styled-content style=\"fixed-case\">AT<\/jats:styled-content>\n                      group, volume of the left putamen did not change, regardless of change in mobility. Similarly, in the\n                      <jats:styled-content style=\"fixed-case\">BAT<\/jats:styled-content>\n                      group, those who improved their mobility most over 12\u00a0months had no change in left putamen volume, although left putamen volume of those who declined in mobility levels decreased significantly.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The primary finding that older adults who engaged in 12\u00a0months of\n                      <jats:styled-content style=\"fixed-case\">BAT<\/jats:styled-content>\n                      training and improved mobility exhibited maintenance of brain volume in an important region responsible for motor control provides compelling evidence that such exercises can contribute to the promotion of functional independence and healthy aging.\n                    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