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Physical activity included walking (goal of 150\u00a0min\/week) and strength, flexibility, and balance training. Health education included workshops on topics relevant to older adults and upper extremity stretching exercises.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n Lifestyle Interventions and Independence in Elders (\n LIFE<\/jats:styled-content>\n ) Study.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Community\u2010dwelling persons aged 70\u201389 with Short Physical Performance Battery scores less than 10 (N\u00a0=\u00a01,635).<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Dyspnea severity (defined as moderate to severe according to a Borg index >2 immediately after a 400\u2010m walk), forced expiratory volume in 1\u00a0second (\n FEV<\/jats:styled-content>\n 1) (<lower limit of normal (\n LLN<\/jats:styled-content>\n ) defined low breathing capacity), and maximal inspiratory pressure (\n MIP<\/jats:styled-content>\n ) (<\n LLN<\/jats:styled-content>\n defined respiratory muscle weakness) were assessed at baseline and 6, 18, and 30\u00a0months. Hospitalization for exacerbation of obstructive airways disease (\n EOAD<\/jats:styled-content>\n ) and pneumonia was also ascertained over the 42\u2010month follow\u2010up period.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The randomized groups were similar in baseline demographics, including mean age (79) and sex (67% female). The effect of physical activity on dyspnea severity,\n FEV<\/jats:styled-content>\n 1, and\n MIP<\/jats:styled-content>\n was no different from that of health education but was associated with higher likelihood of respiratory hospitalization, significantly for\n EOAD<\/jats:styled-content>\n (hazard ratio (\n HR<\/jats:styled-content>\n )\u00a0=\u00a02.34, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.19\u20134.61,\n P<\/jats:italic>\n \u00a0=\u00a0.01) and marginally for pneumonia (\n HR<\/jats:styled-content>\n \u00a0=\u00a01.54, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.98\u20132.42,\n P<\/jats:italic>\n \u00a0=\u00a0.06).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In older persons with mobility limitations, physical activity was associated with higher likelihood of respiratory hospitalization than health education, but differences in dyspnea severity,\n FEV<\/jats:styled-content>\n 1, and\n MIP<\/jats:styled-content>\n did not accompany this effect\u2014indicating that higher hospital use could be attributable to greater participant contact.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14013","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T07:23:58Z","timestamp":1458631438000},"page":"501-509","source":"Crossref","is-referenced-by-count":16,"title":["Effect of Structured Physical Activity on Respiratory Outcomes in Sedentary Elderly Adults with Mobility Limitations"],"prefix":"10.1111","volume":"64","author":[{"given":"Carlos A.","family":"Vaz Fragoso","sequence":"first","affiliation":[{"name":"Veterans Affairs Connecticut West Haven Connecticut"},{"name":"Department of Medicine School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Beavers","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences School of Medicine Wake Forest University 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