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         To assess the associations between incident atrial fibrillation (\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      ) and disability\u2010free survival and risk of disability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Cardiovascular Health Study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Individuals aged 65 and older and enrolled in fee\u2010for\u2010service Medicare followed between 1991 and 2009 (MN = 4,046). Individuals with prevalent\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      , activity of daily living (\n                      <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\n                      ) disability, or a history of stroke or heart failure at baseline were excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Incident\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      was identified according to annual study electrocardiogram, hospital discharge diagnosis, or Medicare claims. Disability\u2010free survival was defined as survival free of\n                      <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\n                      disability (any difficulty or inability in bathing, dressing, eating, using the toilet, walking around the home, or getting out of a bed or chair).\n                      <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\n                      s were assessed at annual study visits or in a telephone interview. Association between incident\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      and disability\u2010free survival or risk of disability was estimated using Cox proportional hazards models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over an average of 7.0 years of follow\u2010up, 660 individuals (16.3%) developed incident\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      , and 3,112 (77%) became disabled or died. Incident\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      was associated with shorter disability\u2010free survival (hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ) for death or\n                      <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\n                      disability = 1.71, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) = 1.55\u20131.90) and a higher risk of\n                      <jats:styled-content style=\"fixed-case\">ADL<\/jats:styled-content>\n                      disability (HR = 1.36, 95% CI = 1.18\u20131.58) than in individuals with no history of\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      . This association persisted after adjustment for interim stroke and heart failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results suggest that\n                      <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n                      is a risk factor for shorter functional longevity in older adults, independent of other risk factors and comorbid conditions.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14037","type":"journal-article","created":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T08:51:58Z","timestamp":1456822318000},"page":"838-843","source":"Crossref","is-referenced-by-count":24,"title":["Incident Atrial Fibrillation and Disability\u2010Free Survival in the Cardiovascular Health 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