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Hartford Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000909","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To examine the relationship between herpesvirus infections and mortality and incident frailty risks in community\u2010dwelling older women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Nested prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Women's Health and Aging Studies I and II.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Community\u2010dwelling older women aged 70 to 79 (n = 633).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Baseline serum antibody (immunoglobulin G) levels against four herpesviruses (herpes simplex virus types 1 (HSV\u20101) and 2 (HSV\u20102), varicella\u2010zoster virus (VZV), 7 Epstein\u2010Barr virus (EBV)), 3\u2010year incident frailty rates, and 5\u2010year mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women seropositive for HSV\u20101 and HSV\u20102, but not VZV and EBV, had higher risk of 3\u2010year incident frailty (HSV\u20101: hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 0.96\u20133.74; HSV\u20102: HR = 2.10, 95% CI = 1.05\u20134.37) and 5\u2010year mortality (HR = 1.73, 95% CI = 0.93\u20133.20; HR = 1.80, 95% CI = 0.94\u20133.44, respectively) than seronegative women. Incremental increases in serum HSV\u20101 and HSV\u20102 antibody levels were associated with incrementally higher risks of incident frailty and mortality. After adjustment for potential confounders, only higher serum HSV\u20102 antibody level was independently predictive of higher risk of mortality in older women (for each unit increase in antibody index, HR = 1.47, 95% CI = 1.05\u20132.07).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HSV\u20101 and HSV\u20102 antibody levels are not independently associated with risk of incident frailty in older women. Only HSV\u20102 antibody level is independently predictive of 5\u2010year mortality risk, with each incremental increase in the antibody level adding further risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14090","type":"journal-article","created":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T07:31:28Z","timestamp":1462087888000},"page":"998-1005","source":"Crossref","is-referenced-by-count":24,"title":["Herpesvirus Infections and Risk of Frailty and Mortality in Older Women: Women's Health and Aging Studies"],"prefix":"10.1111","volume":"64","author":[{"given":"George C.","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology Department of Medicine School of Medicine Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Han","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine and Gerontology Department of 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