{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:14:45Z","timestamp":1782602085072,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T00:00:00Z","timestamp":1466380800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,6]]},"abstract":"\n Objectives<\/jats:title>\n \n To examine whether older people with abnormal thyroid function are more likely to develop chronic kidney disease (\n CKD<\/jats:styled-content>\n ) over a 5\u2010year follow\u2010up period.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Health examination data from the Taipei Databank for Public Health Analysis.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Individuals aged 65 and older (N\u00a0=\u00a041,454).<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Thyroid\u2010stimulating hormone (\n TSH<\/jats:styled-content>\n ) levels were repeatedly measured, and subjects were categorized into four thyroid function groups (hyperthyroid, euthyroid, subclinical hypothyroid, overt hypothyroid). The risk of incident\n CKD<\/jats:styled-content>\n was evaluated using a stepwise Cox proportional hazards regression model adjusted for sex, baseline age, hypertension, diabetes mellitus (\n DM<\/jats:styled-content>\n ), dyslipidemia, hyperuricemia, anemia, obesity, liver function, smoking, and alcohol.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Higher\n TSH<\/jats:styled-content>\n levels were associated with greater risk of subsequent\n CKD<\/jats:styled-content>\n . Individuals with subclinical hypothyroidism (hazard ratio (\n HR<\/jats:styled-content>\n )\u00a0=\u00a01.15, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a01.05\u20131.26) and those with overt hypothyroidism (\n HR<\/jats:styled-content>\n \u00a0=\u00a01.27, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.04\u20131.55) were more likely than those who were euthyroid to have\n CKD<\/jats:styled-content>\n . Women were more likely to have\n CKD<\/jats:styled-content>\n than men (\n HR<\/jats:styled-content>\n \u00a0=\u00a01.11, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.06\u20131.16). When stratified by gender, subclinical hypothyroidism in women was associated with an increased risk of developing CKD (HR = 1.22; 95% CI = 1.08\u20131.39). When stratified by DM, subclinical hypothyroidism and overt hypothyroidism were associated with an increased risk of developing CKD in nondiabetics (HR = 1.19; 95% CI = 1.07\u20131.31; and HR = 1.34; 95% CI = 1.08\u20131.65, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n This cohort study of elderly persons in Taipei City found a significant association between hypothyroidism and development of\n CKD<\/jats:styled-content>\n in women and individuals without\n DM<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14102","type":"journal-article","created":{"date-parts":[[2016,6,20]],"date-time":"2016-06-20T03:29:27Z","timestamp":1466393367000},"page":"1267-1273","source":"Crossref","is-referenced-by-count":38,"title":["Abnormal Thyroid\u2010Stimulating Hormone and Chronic Kidney Disease in Elderly Adults in Taipei City"],"prefix":"10.1111","volume":"64","author":[{"given":"Mei\u2010hsing","family":"Chuang","sequence":"first","affiliation":[{"name":"Division of Family Medicine Department of Community Medicine Taipei City Hospital Taipei Taiwan"},{"name":"Institute of Public Health and Community Medicine Research Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo\u2010Meng","family":"Liao","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine Taipei City Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Min","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Kaohsiung Veterans General Hospital Kaohsiung Taiwan"},{"name":"Institute of Public Health and Community Medicine Research Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Yung\u2010Pou","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology Kaiser Permanente Baldwin Park Medical Center Baldwin Park California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chang","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Education and Research Taipei City Hospital Taipei Taiwan"},{"name":"Institute of Public Health and Community Medicine Research Center National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pesus","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Community Medicine Research Center National Yang\u2010Ming University Taipei 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