{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:30Z","timestamp":1787015550930,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T00:00:00Z","timestamp":1464134400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,5]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine whether moderate\u2010intensity physical activity (\n PA<\/jats:styled-content>\n ) and health education (\n HE<\/jats:styled-content>\n ) are differentially associated with categories of hospitalizations or subgroups of participants.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Multicenter randomized controlled trial in which participants were randomized to a\n PA<\/jats:styled-content>\n or\n HE<\/jats:styled-content>\n program for an average of 2.6\u00a0years.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Eight field centers.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Sedentary men and women aged 70\u201389 with lower extremity physical limitations but able to walk 400\u2010m in 15\u00a0minutes or less (N\u00a0=\u00a01,635).<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n \n Structured, moderate\u2010intensity\n PA<\/jats:styled-content>\n (n\u00a0=\u00a0\u2009818) at a center (2\u00d7\/wk) and at home (3\u20134\u00d7\/wk) that included aerobic, strength, balance, and flexibility training or\n HE<\/jats:styled-content>\n (n\u00a0=\u00a0\u2009817) of educational workshops and upper extremity stretching exercises.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n All\u2010cause inpatient hospitalizations ascertained at 6\u2010month intervals.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 1,458 hospitalizations (49.1% of\n PA<\/jats:styled-content>\n , 44.4% of\n HE<\/jats:styled-content>\n ; risk difference\u00a0=\u00a04.68%, 95% confidence interval (\n CI<\/jats:styled-content>\n )\u00a0=\u00a0\u22120.18\u20139.54; hazard ratio (\n HR<\/jats:styled-content>\n )\u00a0=\u00a01.16, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.00\u20131.34). The intervention effect on incident hospitalization did not differ according to race, sex, Short Physical Performance Battery score, age, or history of cardiovascular disease or diabetes mellitus.\n PA<\/jats:styled-content>\n was associated with higher rates of hospitalization in the middle baseline gait speed category, than\n HE<\/jats:styled-content>\n (<0.8\u00a0m\/s:\n HR<\/jats:styled-content>\n \u00a0=\u00a00.93, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.76\u20131.14; 0.8\u20131.0\u00a0m\/s:\n HR<\/jats:styled-content>\n \u00a0=\u00a01.54, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.23\u20131.94; >1.0\u00a0m\/s:\n HR<\/jats:styled-content>\n \u00a0=\u00a01.05, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.67\u20131.65; interaction\n P<\/jats:italic>\n \u00a0=\u00a0.005).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A\n PA<\/jats:styled-content>\n program in older adults at risk for mobility disability did not lead to a different risk of specific types of hospitalizations than a\n HE<\/jats:styled-content>\n program overall. Baseline gait speed may be a marker for risk of hospitalization during a\n PA<\/jats:styled-content>\n intervention, because individuals with moderate baseline gait speed in the\n PA<\/jats:styled-content>\n group had slightly higher rates of hospitalization than those in the\n HE<\/jats:styled-content>\n group.\n <\/jats:p>\n Trial Registration: ClinicalTrials.gov identifier: NCT01072500.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14114","type":"journal-article","created":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T03:30:57Z","timestamp":1464233457000},"page":"933-943","source":"Crossref","is-referenced-by-count":13,"title":["Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial"],"prefix":"10.1111","volume":"64","author":[{"given":"Anthony P.","family":"Marsh","sequence":"first","affiliation":[{"name":"Department of Health and Exercise Science Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B.","family":"Applegate","sequence":"additional","affiliation":[{"name":"Section\u00a0on Gerontology and Geriatric Medicine Department of Internal Medicine Sticht Center on Aging Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Division of Gerontology Department of Epidemiology and Public Health School of Medicine University of Maryland Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Jack Rejeski","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Church","sequence":"additional","affiliation":[{"name":"Division of Gerontology Department of Epidemiology and Public Health School of Medicine University of Maryland Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Nutrition, Exercise Physiology, and Sarcopenia Laboratory Jean Mayer U.S. Department of Agriculture Human Nutrition Research Center on Aging Tufts University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy School of Medicine Stanford University Stanford California"},{"name":"Department of Medicine School of Medicine Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Section\u00a0on Gerontology and Geriatric Medicine Department of Internal Medicine Sticht Center on Aging Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Manini","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research Institute on Aging College of Medicine University of Florida Gainesville Florida"},{"name":"Department of Medicine and Preventive Medicine Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research Institute on Aging College of Medicine University of Florida Gainesville Florida"},{"name":"Department of Medicine and Preventive Medicine Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Medicine Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Stowe","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Biostatistical Sciences School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Walkup","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Department of Biostatistical Sciences School of Medicine Wake Forest University Winston\u2010Salem 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