{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:45:26Z","timestamp":1790412326274,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:00:00Z","timestamp":1464825600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate perceived fatigability as a predictor of meaningful functional decline in non\u2010mobility\u2010limited older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>\n                      Longitudinal analysis of data from the Baltimore Longitudinal Study of Aging (\n                      <jats:styled-content style=\"fixed-case\">BLSA<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>National Institute on Aging, Clinical Research Unit, Baltimore, Maryland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Men and women aged 60 to 89 participating in the\n                      <jats:styled-content style=\"fixed-case\">BLSA<\/jats:styled-content>\n                      with concurrent perceived fatigability and functional assessments and follow\u2010up functional assessment within 1 to 3\u00a0years (N\u00a0=\u00a0540).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Perceived fatigability was ascertained using the Borg rating of perceived exertion (\n                      <jats:styled-content style=\"fixed-case\">RPE<\/jats:styled-content>\n                      ) after 5\u00a0minutes of treadmill walking at 1.5\u00a0miles per hour. Functional assessments included usual and fast gait speed, the Health, Aging and Body Composition physical performance battery (\n                      <jats:styled-content style=\"fixed-case\">HABC PPB<\/jats:styled-content>\n                      ) and reported walking ability. Reported tiredness and energy level were examined as complementary predictors. Covariates included age, age squared, race, follow\u2010up time, and baseline function. Meaningful decline was defined as 0.05\u00a0m\/s per year for usual gait speed, 0.07\u00a0m\/s per year for fast gait speed, 0.12 points\/year for\n                      <jats:styled-content style=\"fixed-case\">HABC PPB<\/jats:styled-content>\n                      , and 1 point for walking ability index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a mean 2.1\u00a0years, 20\u201331% of participants declined across functional assessments. Fatigability was associated with a 13\u201319% greater likelihood of meaningful decline in all measures (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002\u2013 .02) per 1\u2010unit\n                      <jats:styled-content style=\"fixed-case\">RPE<\/jats:styled-content>\n                      increase. After considering tiredness and energy level separately, findings were essentially unchanged, and neither was associated with gait speed or physical performance decline. In contrast, each separately predicted decline in reported walking ability independent of fatigability (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Routine assessment of fatigability may help identify older persons vulnerable to greater\u2010than\u2010expected functional decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14138","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T10:21:44Z","timestamp":1464862904000},"page":"1287-1292","source":"Crossref","is-referenced-by-count":89,"title":["Fatigued, but Not Frail: Perceived Fatigability as a Marker of Impending Decline in Mobility\u2010Intact Older Adults"],"prefix":"10.1111","volume":"64","author":[{"given":"Eleanor M.","family":"Simonsick","sequence":"first","affiliation":[{"name":"Intramural Research Program National Institute on Aging Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald J.","family":"Jerome","sequence":"additional","affiliation":[{"name":"Department of Kinesiology College of Health Professions Towson University Towson Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Shardell","sequence":"additional","affiliation":[{"name":"Intramural Research Program National Institute on Aging Baltimore 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