{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:37:45Z","timestamp":1773290265565,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,7]]},"abstract":"\n Objectives<\/jats:title>\n \n To examine the effect of statins on long\u2010term mortality in older adults hospitalized with coronary artery disease (\n CAD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective analysis.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n University teaching hospital.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Individuals aged 80 and older (mean aged 85.2, 56% female) hospitalized from January 2006 to December 2010 with acute myocardial infarction (\n AMI<\/jats:styled-content>\n ), unstable angina pectoris, or chronic\n CAD<\/jats:styled-content>\n and discharged alive (N = 1,262). Participants were divided into those who did (n = 913) and did not (n = 349) receive a discharge prescription for a statin.\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n All\u2010cause mortality over a median follow\u2010up of 3.1 years.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants treated with statins were more likely to be male, to have a primary diagnosis of\n AMI<\/jats:styled-content>\n , to have traditional cardiovascular risk factors, and to receive other standard cardiovascular medications in addition to statins. In unadjusted analysis, statin therapy was associated with lower mortality (hazard ratio (\n HR<\/jats:styled-content>\n ) = 0.83, 95% confidence interval (\n CI<\/jats:styled-content>\n ) = 0.71\u20130.96). After adjustment for baseline differences between groups and propensity for receiving statin therapy, the effect of statins on mortality was no longer significant (\n HR<\/jats:styled-content>\n = 0.88, 95%\n CI<\/jats:styled-content>\n = 0.74\u20131.05). The association between statins and mortality was similar in participants aged 80 to 84 and those aged 85 and older.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In this cohort of older adults hospitalized with\n CAD<\/jats:styled-content>\n , statin therapy had no significant effect on long\u2010term survival after adjustment for between\u2010group differences. These findings, although preliminary, call into question the benefit of statin therapy for secondary prevention in a real\u2010world population of adults aged 80 and older and underscore the need for shared decision\u2010making when prescribing statins in this age group.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14207","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T12:57:22Z","timestamp":1465822642000},"page":"1475-1479","source":"Crossref","is-referenced-by-count":21,"title":["Effect of Statin Therapy on Mortality in Older Adults Hospitalized with Coronary Artery Disease: A Propensity\u2010Adjusted Analysis"],"prefix":"10.1111","volume":"64","author":[{"given":"Daniel P.","family":"Rothschild","sequence":"first","affiliation":[{"name":"School of Medicine Washington University St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Novak","sequence":"additional","affiliation":[{"name":"School of Medicine Washington University St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Rich","sequence":"additional","affiliation":[{"name":"School of Medicine Washington University St. Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12788_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12788_2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-10-199705150-00001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437738.63853.7a"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1430"},{"key":"e_1_2_6_8_1","first-page":"85","article-title":"A multivariate technique for multiply imputing missing values using a sequence of regression models","volume":"27","author":"Raghunathan T","year":"2001","journal-title":"Surv Methodol"},{"key":"e_1_2_6_9_1","unstructured":"ParsonsL.Reducing bias in a propensity score matched\u2010pair sample using greedy matching techniques. Presented at 26th Annual SAS Users Group International Conference; April 22\u201325 2001; Long Beach CA. Paper 214\u2013226 [on\u2010line]. Available athttp:\/\/www2.sas.com\/proceedings\/sugi26\/p214-26.pdfAccessed July 13 2015."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-015-7983-4_14"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq129"},{"key":"e_1_2_6_12_1","first-page":"809","article-title":"Pravastatin in elderly individuals at risk of vascular disease (PROSPER)","volume":"57","author":"Shepherd J","year":"2002","journal-title":"Lancet"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-8-201004200-00005"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12170-012-0256-y"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.040"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-012-0291-7"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14207","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:37:01Z","timestamp":1762184221000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/jgs.14207"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14207","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]}}}