{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:10:47Z","timestamp":1791447047489,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T00:00:00Z","timestamp":1467072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To investigate the etiology of transient loss of consciousness (T\u2010\n                      <jats:styled-content style=\"fixed-case\">LOC<\/jats:styled-content>\n                      ) suspected to be syncope and unexplained falls in elderly adults with dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective, observational, multicenter study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Acute care wards, syncope units or centers for the diagnosis of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Individuals aged 65 and older with a diagnosis of dementia and one or more episodes of T\u2010\n                      <jats:styled-content style=\"fixed-case\">LOC<\/jats:styled-content>\n                      of a suspected syncopal nature or unexplained falls during the previous 3 months were enrolled.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      The causes of T\u2010\n                      <jats:styled-content style=\"fixed-case\">LOC<\/jats:styled-content>\n                      suspected to be syncope and unexplained falls were evaluated using a simplified protocol based on European Society of Cardiology guidelines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 357 individuals enrolled, 181 (50.7%) had been referred for T\u2010\n                      <jats:styled-content style=\"fixed-case\">LOC<\/jats:styled-content>\n                      suspected to be syncope, 166 (46.5%) for unexplained falls, and 10 (2.8%) for both. An initially suspected diagnosis of syncope was confirmed in 158 (87.3%), and syncope was identified as the cause of the event in 75 (45.2%) of those referred for unexplained falls. Orthostatic hypotension was the cause of the event in 117 of 242 (48.3%) participants with a final diagnosis of syncope.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The simplified syncope diagnostic protocol can be used in elderly people with dementia referred for suspected syncope or unexplained falls. Unexplained falls may mask a diagnosis of syncope or pseudosyncope in almost 50% of cases. Given the high prevalence of orthostatic syncope in participants (~50%), a systematic reappraisal of drugs potentially responsible for orthostatic hypotension is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14225","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T07:21:23Z","timestamp":1467184883000},"page":"1567-1573","source":"Crossref","is-referenced-by-count":67,"title":["Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study"],"prefix":"10.1111","volume":"64","author":[{"given":"Andrea","family":"Ungar","sequence":"first","affiliation":[{"name":"Syncope Unit Geriatric Cardiology and Medicine University of Florence and Azienda Ospedaliero Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mussi","sequence":"additional","affiliation":[{"name":"Centro di Valutazione e Ricerca Gerontologica University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Ceccofiglio","sequence":"additional","affiliation":[{"name":"Syncope Unit Geriatric Cardiology and Medicine University of Florence and Azienda Ospedaliero Universitaria Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Bellelli","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University of Milano Bicocca Milan Italy"},{"name":"Acute Geriatric Unit San Gerardo Hospital Monza Italy"},{"name":"Milan Center for Neuroscience Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Nicosia","sequence":"additional","affiliation":[{"name":"Medicine and Geriatric Unit Spedali Civili Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Bo","sequence":"additional","affiliation":[{"name":"Struttura Complessa a Direzione Universitaria Geriatria e Malattie Metaboliche dell'Osso Citt\u00e0 della Salute e della Scienza\u2010Molinette Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Riccio","sequence":"additional","affiliation":[{"name":"Geriatric Department SS. 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