{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:43:14Z","timestamp":1792708994018,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T00:00:00Z","timestamp":1466726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000550","name":"British Geriatrics Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine whether delirium in individuals with hip fracture is associated with high C\u2010reactive protein (\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      ), interleukin\u20106 (\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106), and soluble\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106 receptor (\n                      <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\n                      \u20106R) levels in the cerebrospinal fluid (\n                      <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Two university hospitals in Oslo, Norway, and Edinburgh, United Kingdom.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals admitted with acute hip fracture (N = 151).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Participants were assessed for delirium pre\u2010 and postoperatively using the Confusion Assessment Method. Prefracture cognitive impairment was detected using the Informant Questionnaire on Cognitive Decline in the Elderly (\n                      <jats:styled-content style=\"fixed-case\">IQCODE<\/jats:styled-content>\n                      ). Serum was collected preoperatively and\n                      <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                      just before the onset of spinal anesthesia. Cytokine levels in serum and\n                      <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                      samples were determined using an enzyme\u2010linked immunosorbent assay. Student\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests or Mann\u2013Whitney\n                      <jats:italic>U<\/jats:italic>\n                      \u2010tests were used for between\u2010group comparisons. Spearman rho was used for correlations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty participants had prior cognitive impairment (\n                      <jats:styled-content style=\"fixed-case\">IQCODE<\/jats:styled-content>\n                      score \u22653.44). Delirium was diagnosed in 46 participants (77%) with prior cognitive impairment and 25 (29%) without. In participants without prior cognitive impairment,\n                      <jats:styled-content style=\"fixed-case\">CSF CRP<\/jats:styled-content>\n                      levels were higher in participants with delirium (median 0.05 \u03bcg\/mL, interquartile range (\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      ) 0.02\u20130.12 \u03bcg\/mL) than in those without delirium (median 0.01 \u03bcg\/mL,\n                      <jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content>\n                      0.00\u20130.06 \u03bcg\/mL) (\n                      <jats:italic>P<\/jats:italic>\n                      = .01); there were no differences in participants with prior cognitive impairment. In secondary analyses, in participants with prior cognitive impairment, the concentration of\n                      <jats:styled-content style=\"fixed-case\">CSF sIL<\/jats:styled-content>\n                      \u20106R was higher in those participants who developed delirium than in the other subgroups, but this difference was not statistically significant. Serum levels of\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106, and\n                      <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\n                      \u20106R were not different according to delirium in participants with or without prefracture cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      High\n                      <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>\n                      levels of\n                      <jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\n                      \u20106R may be associated with delirium. Different pathophysiological mechanisms may operate in different subgroups, notably in relation to the presence of prior cognitive impairment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14238","type":"journal-article","created":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T21:41:10Z","timestamp":1466890870000},"page":"1456-1463","source":"Crossref","is-referenced-by-count":89,"title":["Associations Between Delirium and Preoperative Cerebrospinal Fluid C\u2010Reactive Protein, Interleukin\u20106, and Interleukin\u20106 Receptor in Individuals with Acute Hip Fracture"],"prefix":"10.1111","volume":"64","author":[{"given":"Bj\u00f8rn Erik","family":"Neerland","sequence":"first","affiliation":[{"name":"Oslo Delirium Research Group Department of Geriatric Medicine Oslo University Hospital Oslo Norway"},{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roanna J.","family":"Hall","sequence":"additional","affiliation":[{"name":"Edinburgh Delirium Research Group University of Edinburgh Edinburgh UK"},{"name":"Centre for Cognitive Ageing and Cognitive Epidemiology University of Edinburgh Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingebj\u00f8rg","family":"Seljeflot","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine University of Oslo Oslo Norway"},{"name":"Center for Clinical Heart Research Department of Cardiology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frede","family":"Frihagen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alasdair M. 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