{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:10:05Z","timestamp":1785553805166,"version":"3.56.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"publisher","award":["P30 AG\u2010021332"],"award-info":[{"award-number":["P30 AG\u2010021332"]}],"id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009858","name":"Gabrielle\u2019s Angel Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To measure short\u2010term changes in physical and cognitive function and emotional well\u2010being of older adults receiving intensive chemotherapy for acute myeloid leukemia (\n                      <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Single academic institution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Individuals aged 60 and older with newly diagnosed\n                      <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                      who received induction chemotherapy (N = 49, mean age 70 \u00b1 6.2, 56% male).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Geriatric assessment (\n                      <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\n                      ) was performed during inpatient examination for\n                      <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                      and within 8 weeks after hospital discharge after induction chemotherapy. Measures were the Pepper Assessment Tool for Disability (activity of daily living, instrumental activity of daily living (\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      ), mobility questions), Short Physical Performance Battery (\n                      <jats:styled-content style=\"fixed-case\">SPPB<\/jats:styled-content>\n                      ), grip strength, Modified Mini\u2010Mental State examination, Center for Epidemiologic Studies Depression Scale, and the Distress Thermometer. Changes in\n                      <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\n                      measures were assessed using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests. Analysis of variance models were used to evaluate relationships between\n                      <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content>\n                      variables and change in function over time.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After chemotherapy,\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      dependence worsened (mean 1.4 baseline vs 2.1 follow\u2010up,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001), as did mean\n                      <jats:styled-content style=\"fixed-case\">SPPB<\/jats:styled-content>\n                      scores (7.5 vs 5.9,\n                      <jats:italic>P<\/jats:italic>\n                      = .02 for total). Grip strength also declined (38.9 \u00b1 7.7 vs 34.2 \u00b1 10.3 kg,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001 for men; 24.5 \u00b1 4.8 vs 21.8 \u00b1 4.7 kg,\n                      <jats:italic>P<\/jats:italic>\n                      = .007 for women). No significant changes in cognitive function (mean 84.7 vs 85.1,\n                      <jats:italic>P<\/jats:italic>\n                      = .72) or depressive symptoms (14.0 vs. 11.3,\n                      <jats:italic>P<\/jats:italic>\n                      = .11) were detected, but symptoms of distress declined (5.0 vs 3.2,\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001). Participants with depressive symptoms at baseline and follow\u2010up had greater declines in\n                      <jats:styled-content style=\"fixed-case\">SPPB<\/jats:styled-content>\n                      scores those without at both time points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Short\u2010term survivors of intensive chemotherapy for\n                      <jats:styled-content style=\"fixed-case\">AML<\/jats:styled-content>\n                      had clinically meaningful declines in physical function. These data support the importance of interventions to maintain physical function during and after chemotherapy. Depressive symptoms before and during chemotherapy may be linked to potentially modifiable physical function declines.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14301","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T11:03:03Z","timestamp":1473850983000},"page":"1988-1995","source":"Crossref","is-referenced-by-count":90,"title":["Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia"],"prefix":"10.1111","volume":"64","author":[{"given":"Heidi D.","family":"Klepin","sequence":"first","affiliation":[{"name":"Wake Forest Baptist Comprehensive Cancer Center Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet A.","family":"Tooze","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Wake Forest School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Pardee","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Comprehensive Cancer Center Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie R.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Comprehensive Cancer Center Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitriy","family":"Berenzon","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Comprehensive Cancer Center Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L.","family":"Mihalko","sequence":"additional","affiliation":[{"name":"Wake Forest University Department of Health and Exercise Science Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne C.","family":"Danhauer","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences Wake Forest School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arati V.","family":"Rao","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Wildes","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff D.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayard L.","family":"Powell","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Comprehensive Cancer Center Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Section on Gerontology and Geriatric Medicine Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"SEER Cancer Statistics Review 1975\u20132009 [on\u2010line]. 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