{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T07:50:59Z","timestamp":1784793059919,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG005407"],"award-info":[{"award-number":["R01 AG005407"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35582"],"award-info":[{"award-number":["R01 AR35582"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35583"],"award-info":[{"award-number":["R01 AR35583"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AR35584"],"award-info":[{"award-number":["R01 AR35584"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG005394"],"award-info":[{"award-number":["R01 AG005394"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG027574"],"award-info":[{"award-number":["R01 AG027574"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG027576"],"award-info":[{"award-number":["R01 AG027576"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the relationship between life\u2010space mobility (extent, frequency, independence of movement) and mortality in older women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Four U.S. clinical sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Women (N = 1,498) aged 75 to 102 (mean 87.6) followed from 2006 to 2015.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Life\u2010space during the past 4 weeks was assessed in an interview, scored from 0 (daily restriction to bedroom) to 120 (daily trips outside town without assistance), and categorized (0\u201320, 21\u201340, 41\u201360, 61\u201380, 81\u2013120). All\u2010cause mortality was the primary outcome; noncancer, cardiovascular, cancer, and noncardiovascular noncancer mortality were secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a mean 5.2 years, 842 (56.2%) women died. Unadjusted risk of all\u2010cause mortality was 82.6% in women with the lowest level of life\u2010space (0\u201320 points) and 36.2% in those with the highest level (81\u2013120 points). In multivariable proportional hazards models, there was a strong relationship between less life\u2010space and greater risk of all\u2010cause mortality (\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>trend<\/jats:sub>\n                      &lt; .001). Women with the lowest level of life\u2010space (0\u201320 points) had a risk of all\u2010cause mortality that was 2.4 times as high (95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) = 1.5\u20134.0) as that of women with the highest level (81\u2013120 points); women with life\u2010space scores between 21 and 60 had a risk of all\u2010cause mortality that was 1.5 times as high as that of women with the highest level. Each standard deviation decrease in life\u2010space was associated with a 1.2 times greater (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = 1.1\u20131.4) risk of all\u2010cause mortality. Women unable to travel beyond their neighborhood without assistance had a risk of all\u2010cause mortality that was 1.4 times (95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = 1.1\u20131.7) as high as that of women who could travel beyond their neighborhood without assistance. Results were similar for noncancer, cardiovascular, and other mortality and did not change after controlling for underlying disease or living arrangement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Life\u2010space scores of 60 or less were associated with mortality in older women independent of other strong risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14474","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T14:28:28Z","timestamp":1476196108000},"page":"2226-2234","source":"Crossref","is-referenced-by-count":46,"title":["Life\u2010Space Mobility and Mortality in Older Women: Prospective Results from the Study of Osteoporotic Fractures"],"prefix":"10.1111","volume":"64","author":[{"given":"Dawn C.","family":"Mackey","sequence":"first","affiliation":[{"name":"Department of Biomedical Physiology and Kinesiology Simon Fraser University Burnaby British Columbia Canada"},{"name":"Centre for Hip Health and Mobility University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Yung","family":"Lui","sequence":"additional","affiliation":[{"name":"Research Institute California Pacific Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy M.","family":"Cawthon","sequence":"additional","affiliation":[{"name":"Research Institute California Pacific Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Ensrud","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[{"name":"San Francisco Veterans Affairs Medical Centre University of California, San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Research Institute California Pacific Medical Center San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3033"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-010-1543-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540030039029"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.2.171"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2018"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51512.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/85.10.1008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-6-200903170-00005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2014.917607"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12787"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnq013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12763"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm270"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/63.11.1241"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JGP.0b013e318211c219"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264313497507"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12892"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4460"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.03.027"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04077.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-10-55"},{"key":"e_1_2_6_24_1","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) examination","volume":"48","author":"Teng EL","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.82"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503233321202"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199910)14:10<858::AID-GPS35>3.0.CO;2-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01062.x"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2014.07.006"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03430170057028"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PSY.0000041470.25130.6C"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls133"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthplace.2015.05.001"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264314555328"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0144686X12000517"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181a819a1"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14474","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14474","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14474","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:04:39Z","timestamp":1762200279000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/jgs.14474"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14474","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]}}}