{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T21:09:01Z","timestamp":1780520941718,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T00:00:00Z","timestamp":1474934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>\n                    Common bile duct (\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    ) stones are common in elderly adults, but the effect of aging on the presentation of\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones remains to be evaluated. Recent studies have demonstrated that the clinical presentation of\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones may vary with age. Younger adults may present with classical biliary colic symptoms, whereas elderly adults may have no unapparent clinical features. Younger adults with\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones were significantly more likely to have abnormal liver function tests than those without. The sensitivity and accuracy of transabdominal ultrasound scans in screening for\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones increases with age. Antibiotic agents should be promptly administered to individuals with\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones complicated by cholangitis, but the effects of pharmacotherapy on renal function should be considered in elderly adults. Endoscopic retrograde cholangiopancreatography (\n                    <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>\n                    ) is considered to be first\u2010line treatment for\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones, and endoscopic biliary sphincterotomy (\n                    <jats:styled-content style=\"fixed-case\">EST<\/jats:styled-content>\n                    ) or endoscopic papillary balloon dilation (\n                    <jats:styled-content style=\"fixed-case\">EPBD<\/jats:styled-content>\n                    ) along with\n                    <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>\n                    is an adequate biliary drainage method in individuals with\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones.\n                    <jats:styled-content style=\"fixed-case\">EPBD<\/jats:styled-content>\n                    has a lower bleeding risk but higher post\u2010\n                    <jats:styled-content style=\"fixed-case\">ERCP<\/jats:styled-content>\n                    risk of pancreatitis than\n                    <jats:styled-content style=\"fixed-case\">EST<\/jats:styled-content>\n                    . Longer\u2010duration (&gt;1 minute)\n                    <jats:styled-content style=\"fixed-case\">EPBD<\/jats:styled-content>\n                    may be preferred over\n                    <jats:styled-content style=\"fixed-case\">EST<\/jats:styled-content>\n                    because it is associated with a comparable risk of pancreatitis but a lower rate of overall complications, although recurrent cholangitis or unfavorable outcomes will increase during\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    dilation or in the presence of residual\n                    <jats:styled-content style=\"fixed-case\">CBD<\/jats:styled-content>\n                    stones.\n                  <\/jats:p>","DOI":"10.1111\/jgs.14481","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T12:07:37Z","timestamp":1474978057000},"page":"2330-2335","source":"Crossref","is-referenced-by-count":17,"title":["How Does Aging Affect Presentation and Management of Biliary Stones?"],"prefix":"10.1111","volume":"64","author":[{"given":"Kuang\u2010Chun","family":"Hu","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan"},{"name":"Healthy Evaluation Center MacKay Memorial Hospital Taipei Taiwan"},{"name":"MacKay Medical, Nursing, and Management College Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine College of Medicine National Taiwan University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Hsin","family":"Chu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Department of Internal Medicine MacKay Memorial Hospital Taipei Taiwan"},{"name":"MacKay Medical, Nursing, and Management College Taipei 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