{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:53:56Z","timestamp":1790751236157,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T00:00:00Z","timestamp":1477440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG023712"],"award-info":[{"award-number":["U01\u2010AG023712"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG23744"],"award-info":[{"award-number":["U01\u2010AG23744"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG023746"],"award-info":[{"award-number":["U01\u2010AG023746"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG023749"],"award-info":[{"award-number":["U01\u2010AG023749"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01\u2010AG023755"],"award-info":[{"award-number":["U01\u2010AG023755"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine reference values for laboratory tests in individuals aged 85 and older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>International.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Long Life Family Study (LLFS) participants (N~5,000, age: range 25\u2013110, median 67, 45% male).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Serum biomarkers were selected based on association with aging\u2010related diseases and included complete blood count, lipids (triglycerides, high\u2010density lipoprotein cholesterol, low\u2010density lipoprotein cholesterol, total cholesterol), 25\u2010hydroxyvitamin D2 and D3, vitamin D epi\u2010isomer, diabetes mellitus\u2013related biomarkers (adiponectin, insulin, insulin\u2010like growth factor 1, glucose, glycosylated hemoglobin, soluble receptor for advanced glycation endproduct), kidney disease\u2013related biomarkers (albumin, creatinine, cystatin), endocrine biomarkers (dehydroepiandrosterone, sex\u2010hormone binding globulin, testosterone), markers of inflammation (interleukin 6, high\u2010sensitivity C\u2010reactive protein, N\u2010terminal pro b\u2010type natriuretic peptide), ferritin, and transferrin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 38 measured biomarkers, 34 were significantly correlated with age. Summary statistics were generated for all biomarkers according to sex and 5\u2010year age increments from 50 and up after excluding participants with diseases and treatments that were associated with biomarkers. A biomarker data set was also generated that will be useful for other investigators seeking to compare biomarker levels between studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Levels of several biomarkers change with older age in healthy individuals. The descriptive statistics identified herein will be useful in future studies and, if replicated in additional studies, might also become useful in clinical practice. The availability of the reference data set will facilitate appropriate calibration of biomarkers measured in different laboratories.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14522","type":"journal-article","created":{"date-parts":[[2016,10,26]],"date-time":"2016-10-26T11:07:10Z","timestamp":1477480030000},"source":"Crossref","is-referenced-by-count":49,"title":["Age and Sex Distributions of Age\u2010Related Biomarker Values in Healthy Older Adults from the Long Life Family Study"],"prefix":"10.1111","volume":"64","author":[{"given":"Paola","family":"Sebastiani","sequence":"first","affiliation":[{"name":"Department of Biostatistics School of Public Health Boston University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharat","family":"Thyagarajan","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology Medical School University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biostatistics School of Public Health Boston University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Honig","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Science and Physicians Sergievsky Center Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Schupf","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Mailman School of Public Health Sergievsky Center Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Cosentino","sequence":"additional","affiliation":[{"name":"Department of Neurology College of Science and Physicians Sergievsky Center Columbia University New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Feitosa","sequence":"additional","affiliation":[{"name":"Department of Genetics School of Medicine Washington University St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Wojczynski","sequence":"additional","affiliation":[{"name":"Department of Genetics School of Medicine Washington University St. Louis Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monty","family":"Montano","sequence":"additional","affiliation":[{"name":"Department of Medicine Harvard Medical School Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Perls","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine and Geriatric Section Boston University Boston Medical Center Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-011-0355-3"},{"key":"e_1_2_6_3_1","first-page":"25","volume-title":"Projections of the Size and Composition of the U.S. Population: 2014 to 2060","author":"Colby S","year":"2014"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2011.01.001"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Plan and operations, 1999\u20132010","volume":"1","author":"Zipf G","year":"2013","journal-title":"Vital Health Stat"},{"key":"e_1_2_6_6_1","unstructured":"Test ID: PBNP: NT\u2010Pro B\u2010Type Natriuretic Peptide (BNP) Serum[on\u2010line]. 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