{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:08:36Z","timestamp":1789967316538,"version":"4.0.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,14]],"date-time":"2016-11-14T00:00:00Z","timestamp":1479081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000774","name":"Newcastle University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To examine the Framingham Stroke Risk Profile (\n                      <jats:styled-content style=\"fixed-case\">FSRP<\/jats:styled-content>\n                      ); the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (\n                      <jats:styled-content style=\"fixed-case\">CAIDE<\/jats:styled-content>\n                      ) risk score, and oxi\u2010inflammatory load (cumulative risk score of three blood biomarkers\u2014homocysteine, interleukin\u20106, C\u2010reactive protein) for associations with cognitive decline using three cohort studies of very old adults and to examine whether incorporating these biomarkers with the risk scores can affect the association with cognitive decline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Three longitudinal, population\u2010based cohort studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Newcastle\u2010upon\u2010Tyne, United Kingdom; Leiden, the Netherlands; and Lakes and Bay of Plenty District Health Board areas, New Zealand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Newcastle 85+ Study participants (n = 616), Leiden 85\u2010plus Study participants (n = 444), and Life and Living in Advanced Age, a Cohort Study in New Zealand (Li\n                      <jats:styled-content style=\"fixed-case\">LACS NZ<\/jats:styled-content>\n                      Study) participants (n = 396).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">FSRP<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">CAIDE<\/jats:styled-content>\n                      risk score, oxi\u2010inflammatory load,\n                      <jats:styled-content style=\"fixed-case\">FSRP<\/jats:styled-content>\n                      incorporating oxi\u2010inflammatory load, and\n                      <jats:styled-content style=\"fixed-case\">CAIDE<\/jats:styled-content>\n                      risk score incorporating oxi\u2010inflammatory load. Oxi\u2010inflammatory load could be calculated only in the Newcastle 85+ and the Leiden 85\u2010plus studies. Measures of global cognitive function were available for all three data sets. Domain\u2010specific measures were available for the Newcastle 85+ and the Leiden 85\u2010plus studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Meta\u2010analysis of pooled results showed greater risk of incident global cognitive impairment with higher\n                      <jats:styled-content style=\"fixed-case\">FSRP<\/jats:styled-content>\n                      (hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      ) = 1.46, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      ) = 1.08\u20131.98),\n                      <jats:styled-content style=\"fixed-case\">CAIDE<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      = 1.53, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = 1.09\u20132.14), and oxi\u2010inflammatory load (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      = 1.73, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = 1.04\u20132.88) scores. Adding oxi\u2010inflammatory load to the risk scores increased the risk of cognitive impairment for the\n                      <jats:styled-content style=\"fixed-case\">FSRP<\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      = 1.65, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = 1.17\u20132.33) and the\n                      <jats:styled-content style=\"fixed-case\">CAIDE<\/jats:styled-content>\n                      model (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      = 1.93, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      = 1.39\u20132.67).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Adding oxi\u2010inflammatory load to cardiovascular risk scores may be useful for determining risk of cognitive impairment in very old adults.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14532","type":"journal-article","created":{"date-parts":[[2016,11,16]],"date-time":"2016-11-16T11:54:27Z","timestamp":1479297267000},"page":"381-389","source":"Crossref","is-referenced-by-count":36,"title":["Predicting Risk of Cognitive Decline in Very Old Adults Using Three Models: The Framingham Stroke Risk Profile; the Cardiovascular Risk Factors, Aging, and Dementia Model; and Oxi\u2010Inflammatory Biomarkers"],"prefix":"10.1111","volume":"65","author":[{"given":"Stephanie L.","family":"Harrison","sequence":"first","affiliation":[{"name":"Institute of Health and Society Newcastle University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton J. M.","family":"de Craen","sequence":"additional","affiliation":[{"name":"Department of Gerontology and Geriatrics Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngaire","family":"Kerse","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Health Care School of Population Health University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Teh","sequence":"additional","affiliation":[{"name":"Department of General Practice and Primary Health Care School of Population Health University of Auckland Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoneta","family":"Granic","sequence":"additional","affiliation":[{"name":"Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"},{"name":"Ageing Geriatrics and Epidemiology Institute of Neuroscience National Institute for Health Research Newcastle Biomedical Research Centre in Ageing and Chronic Disease Newcastle University and Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"},{"name":"Ageing Geriatrics and Epidemiology Institute of Neuroscience National Institute for Health Research Newcastle Biomedical Research Centre in Ageing and Chronic Disease Newcastle University and Newcastle upon Tyne NHS Foundation Trust Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Wesnes","sequence":"additional","affiliation":[{"name":"Wesnes Cognition Ltd Streatley on Thames United Kingdom"},{"name":"Department of Psychology Northumbria University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy P. J.","family":"den Elzen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Public Health and Primary Care Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobijn","family":"Gussekloo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care Leiden University Medical Center Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas B. L.","family":"Kirkwood","sequence":"additional","affiliation":[{"name":"Institute of Cell and Molecular Biosciences Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Robinson","sequence":"additional","affiliation":[{"name":"Institute of Health and Society Newcastle University Newcastle upon Tyne United Kingdom"},{"name":"Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Jagger","sequence":"additional","affiliation":[{"name":"Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Siervo","sequence":"additional","affiliation":[{"name":"Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"},{"name":"Institute of Cellular Medicine Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blossom C. M.","family":"Stephan","sequence":"additional","affiliation":[{"name":"Institute of Health and Society Newcastle University Newcastle upon Tyne United Kingdom"},{"name":"Institute of Ageing Campus for Ageing and Vitality Newcastle University Newcastle upon Tyne United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S1839"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.699579"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70537-3"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.482570"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/56.6.P340"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.07.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828ab370"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr133"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afs166"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31829a352e"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31822f9089"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318236ef23"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000343276"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afm051"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.2.511"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2010.54"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-06650-9"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.3.312"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b4904"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-10-64"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114431"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000103141.82869.77"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-8-12"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108370"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00505-X"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-12-33"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv103"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a3083"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2011.08.001"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004754"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12539"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324437"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.4.866"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(09)00408-5"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05726.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-2395-2-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06651.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136181"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T19:18:58Z","timestamp":1762197538000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,14]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1111\/jgs.14532"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14532","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,14]]}}}