{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:40:40Z","timestamp":1762195240017,"version":"build-2065373602"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,27]],"date-time":"2016-11-27T00:00:00Z","timestamp":1480204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute heart failure is a common cause of hospitalization among older patients. Optimized risk stratification might improve the outcome for this subgroup of patients. Natriuretic peptides have been used in the diagnosis of heart failure and in evaluating the prognosis of patients hospitalized for heart failure. However, their utility in the elderly is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate long\u2010term survival and prognostic factors for elderly patients hospitalized for acutely decompensated heart failure and evaluate the prognostic utility of NT\u2010proBNP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective, multicenter cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Two Italian hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Two hundred seventy\u2010nine patients, aged &gt;75 years; hospitalized for decompensation of chronic, established heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Baseline clinical data were recorded at admission. The primary outcome was long\u2010term mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In\u2010hospital, 12\u2010month and 5\u2010year mortality were, respectively, 10%, 36%, and 77%. NT\u2010proBNP,\n                      <jats:styled-content style=\"fixed-case\">eGFR<\/jats:styled-content>\n                      , hemoglobin, diabetes, systolic blood pressure, and moderate to severe tricuspid regurgitation were independently associated with long\u2010term prognosis and were entered into a multivariate model, with a C\u2010index of 0.765 for the determination of high\u2010risk patients. The C\u2010index for NT\u2010proBNP to predict mortality at 2 and 12 months was 0.740 and 0.756, respectively. The optimal cutoff point for predicting mortality at 2 and 12 months was 8,444 pg\/mL (hazard ratio 5.33) and 8,275 pg\/mL (hazard ratio 6.03), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elderly patients hospitalized for acutely decompensated heart failure had a poor long\u2010term outcome, especially in the subgroup with reduced ejection fraction (EF). In addition to EF and comorbidities, NT\u2010pro\u2010BNP remained independently prognostic among elderly patients hospitalized with heart failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14561","type":"journal-article","created":{"date-parts":[[2016,11,27]],"date-time":"2016-11-27T06:22:45Z","timestamp":1480227765000},"page":"822-826","source":"Crossref","is-referenced-by-count":13,"title":["Predictors of Long\u2010Term Mortality in Older Patients Hospitalized for Acutely Decompensated Heart Failure: Clinical Relevance of Natriuretic Peptides"],"prefix":"10.1111","volume":"65","author":[{"given":"Andrea","family":"Passantino","sequence":"first","affiliation":[{"name":"Division of Cardiology and Cardiac Rehabilitation \u201cS. Maugeri\u201d Foundation IRCCS, Institute of Cassano Murge Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Guida","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiac Rehabilitation \u201cS. Maugeri\u201d Foundation IRCCS, Institute of Cassano Murge Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Lagioia","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiac Rehabilitation \u201cS. Maugeri\u201d Foundation IRCCS, Institute of Cassano Murge Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Ammirati","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department Niguarda Ca\u2019 Granda Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Oliva","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department Niguarda Ca\u2019 Granda Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Frigerio","sequence":"additional","affiliation":[{"name":"Cardiothoracic and Vascular Department Niguarda Ca\u2019 Granda Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Scrutinio","sequence":"additional","affiliation":[{"name":"Division of Cardiology and Cardiac Rehabilitation \u201cS. Maugeri\u201d Foundation IRCCS, Institute of Cassano Murge Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020115"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.07.064"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2015.07.010"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl443"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn539"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2007.11.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.21.2282"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02407.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.08.015"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.12.012"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2010.00180.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.17.1892"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.037"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi631"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2008.01.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq509"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.3.315"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02059-4"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-14-128"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.137"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.330"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.5.572"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2004.11.026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.04.030"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfq167"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.19.2581"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu144"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-0405"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(03)00740-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)89163-1"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:20:23Z","timestamp":1762194023000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,27]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jgs.14561"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14561","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"type":"print","value":"0002-8614"},{"type":"electronic","value":"1532-5415"}],"subject":[],"published":{"date-parts":[[2016,11,27]]}}}