{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:15:59Z","timestamp":1784272559805,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T00:00:00Z","timestamp":1489104000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004426","name":"Atlantic Philanthropies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004426","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001582","name":"Centre for Ageing Research and Development in Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Objectives<\/jats:title>\n \n Cardiovascular disorders are recognized as important modifiable risk factors for falls. However, the association between falls and orthostatic hypotension (\n OH<\/jats:styled-content>\n ) remains ambivalent, particularly because of poor measurement methods of previous studies. The goal was to determine for the first time to what extent\n OH<\/jats:styled-content>\n (and variants) are risk factors for incident falls, unexplained falls (\n UF<\/jats:styled-content>\n ), injurious falls (\n IF<\/jats:styled-content>\n ) and syncope using dynamic blood pressure (\n BP<\/jats:styled-content>\n ) measurements in a population study.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Nationally representative longitudinal cohort study\u2013The Irish Longitudinal Study on Ageing (\n TILDA<\/jats:styled-content>\n )\u2013wave 1 (2009\u20132011) with 2\u2010year follow\u2010up at wave 2 (2012\u20132013).\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Community\u2010dwelling adults.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Four thousand one hundred twenty\u2010seven participants were randomly sampled from the population of older adults aged \u226550 years resident in Ireland.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Continuous\n BP<\/jats:styled-content>\n recordings measured during active stands were analyzed.\n OH<\/jats:styled-content>\n and variants (initial\n OH<\/jats:styled-content>\n and impaired orthostatic\n BP<\/jats:styled-content>\n stabilization\n OH<\/jats:styled-content>\n (40)) were defined using dynamic\n BP<\/jats:styled-content>\n measurements. Associations with the number of falls,\n UF<\/jats:styled-content>\n ,\n IF<\/jats:styled-content>\n , and syncope reported 2 years later were assessed using negative binomial and modified Poisson regression as appropriate.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Participants had a mean age of 61.5 (8.2) years (54.2% female).\n OH<\/jats:styled-content>\n (40) was associated with increased relative risk of\n UF<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n : 1.52 95%\n CI<\/jats:styled-content>\n : 1.03\u20132.26).\n OH<\/jats:styled-content>\n was associated with all\u2010cause falls (\n IRR<\/jats:styled-content>\n : 1.40 95%\n CI<\/jats:styled-content>\n : 1.01\u20131.96),\n UF<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n : 1.81 95%\n CI<\/jats:styled-content>\n : 1.06\u20133.09), and\n IF<\/jats:styled-content>\n (\n RR<\/jats:styled-content>\n : 1.58 95%\n CI<\/jats:styled-content>\n : 1.12\u20132.24).\n IOH<\/jats:styled-content>\n was not associated with any outcome.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n With the exception of initial orthostatic hypotension, beat\u2010to\u2010beat measures of impaired orthostatic\n BP<\/jats:styled-content>\n recovery (delayed recovery OH (40) or sustained orthostatic hypotension OH) are independent risk factors for future falls, unexplained falls, and injurious falls.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14563","type":"journal-article","created":{"date-parts":[[2017,3,10]],"date-time":"2017-03-10T10:26:33Z","timestamp":1489141593000},"page":"474-482","source":"Crossref","is-referenced-by-count":129,"title":["Impaired Orthostatic Blood Pressure Recovery Is Associated with Unexplained and Injurious Falls"],"prefix":"10.1111","volume":"65","author":[{"given":"Ciar\u00e1n","family":"Finucane","sequence":"first","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Department of Medical Gerontology Trinity College Dublin Dublin Ireland"},{"name":"Department of Medical Physics and Bioengineering Dublin Ireland"},{"name":"Mercer's Institute for Successful Ageing St. James's Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D. L.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Department of Medical Gerontology Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orna","family":"Donoghue","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Department of Medical Gerontology Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Richardson","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of East Anglia Norwich Research Park Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Savva","sequence":"additional","affiliation":[{"name":"School of Health Sciences University of East Anglia Norwich Research Park Norwich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"The Irish Longitudinal Study on Ageing (TILDA) Department of Medical Gerontology Trinity College Dublin Dublin Ireland"},{"name":"Mercer's Institute for Successful Ageing St. James's Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,10]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Centers for Disease Control and Prevention.Web\u2013based Injury Statistics Query and Reporting System (WISQARS) 2013. 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Available atwww.cdc.gov\/homeandrecreationalsafety\/falls\/adultfalls.htmlAccessed December 02 2016."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2012.03.033"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904203201606"},{"key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/j.1532-5415.2010.03234.x","article-title":"Society clinical practice guideline for prevention of falls in older persons","volume":"59","author":"Summary of the Updated American Geriatrics Society\/British Geriatrics","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012407"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2012.11.006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.08.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afu164"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009831"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012884"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03317.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-013-0219-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12199"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12197"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr116"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","unstructured":"SoraghanCJ FanCW HayakawaTet al.TILDA Signal Processing Framework (SPF) for the analysis of BP responses to standing in epidemiological and clinical studies. 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