{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:34:53Z","timestamp":1785526493636,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institutes of Health\/National Institute on Aging","award":["U01 AG006786"],"award-info":[{"award-number":["U01 AG006786"]}]},{"name":"National Institutes of Health\/National Institute on Aging","award":["R01 AG011378"],"award-info":[{"award-number":["R01 AG011378"]}]},{"name":"National Institutes of Health\/National Institute on Aging","award":["R01 AG041851"],"award-info":[{"award-number":["R01 AG041851"]}]},{"name":"National Institutes of Health\/National Institute on Aging","award":["R01 AG049704"],"award-info":[{"award-number":["R01 AG049704"]}]},{"name":"Rochester Epidemiology Project","award":["R01 AG034676"],"award-info":[{"award-number":["R01 AG034676"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To determine the cross\u2010sectional association between cerebral amyloid\u2010beta (A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      ) deposition and gait.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>\n                      Population\u2010based cohort study in Olmsted County,\n                      <jats:styled-content style=\"fixed-case\">MN<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Cognitively normal individuals (n = 611), aged 50 to 69 years, enrolled in the Mayo Clinic Study of Aging with concurrent PiB\u2010\n                      <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\n                      imaging and gait assessment. Participants with a history of stroke, alcoholism, Parkinson's disease, subdural hematoma, traumatic brain injury, or normal pressure hydrocephalus were excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      PiB\u2010\n                      <jats:styled-content style=\"fixed-case\">PET SUVR<\/jats:styled-content>\n                      was measured in prefrontal, orbitofrontal, parietal, temporal, anterior cingulate, posterior cingulate, and motor\u2010specific regions of interest (\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      s). Gait parameters (speed, cadence, stride length, double support time, and intra\u2010individual stance time variability) were measured using\n                      <jats:styled-content style=\"fixed-case\">GAITR<\/jats:styled-content>\n                      ite\n                      <jats:sup>\u00ae<\/jats:sup>\n                      instrumentation. Linear regression models were adjusted for age, sex, body mass index, education,\n                      <jats:styled-content style=\"fixed-case\">APOE<\/jats:styled-content>\n                      <jats:italic>\u03b5<\/jats:italic>\n                      4 allele, Charlson comorbidity index, and depression. In secondary analyses, we additionally adjusted for neurodegeneration (hippocampal volume,\n                      <jats:styled-content style=\"fixed-case\">FDG PET SUVR<\/jats:styled-content>\n                      , and cortical thickness) in\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      \u2010associated regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In fully adjusted models including neuroimaging measures of neurodegeneration, higher PiB\u2010\n                      <jats:styled-content style=\"fixed-case\">PET SUVR<\/jats:styled-content>\n                      across all\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      s was associated with slower gait speed (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05 except for the parietal\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      ), lower cadence and longer double support time (\n                      <jats:italic>P<\/jats:italic>\n                      \u2264 .05 except for the motor\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      ), and greater stance time variability (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .05). In sex\u2010stratified analyses, the association between higher PiB\u2010\n                      <jats:styled-content style=\"fixed-case\">PET SUVR<\/jats:styled-content>\n                      across all\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      s and measures of gait was only present among women.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      PiB\u2010\n                      <jats:styled-content style=\"fixed-case\">PET SUVR<\/jats:styled-content>\n                      across\n                      <jats:styled-content style=\"fixed-case\">ROI<\/jats:styled-content>\n                      s, independent of general measures of\n                      <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                      \u2010associated neurodegeneration, is associated with poorer performance on multiple gait parameters among cognitively normal women, aged 50 to 69 years. Longitudinal studies are needed to determine whether A\n                      <jats:italic>\u03b2<\/jats:italic>\n                      predicts gait decline in both women and men.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14670","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T07:22:44Z","timestamp":1479712964000},"page":"792-799","source":"Crossref","is-referenced-by-count":53,"title":["Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging"],"prefix":"10.1111","volume":"65","author":[{"given":"Alexandra M. V.","family":"Wennberg","sequence":"first","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Savica","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton E.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosebud O.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Knopman","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Hollman","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanthi","family":"Vemuri","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Mielke","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Research Mayo Clinic Rochester Minnesota"},{"name":"Department of Neurology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00580.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0246-z"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt089"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.05.019"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.05.007"},{"key":"e_1_2_6_7_1","first-page":"189","article-title":"Vascular burden as a substrate for higher\u2010level gait disorders in older adults. A review of brain mapping literature","volume":"54","author":"Annweiler C","year":"2012","journal-title":"Panminerva Med"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.610360"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002235"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4821"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys195"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000115751"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2011.03.024"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22628"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.02.005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2009.07.002"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2321"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.108.058529"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.11.058"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000386"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn113"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.12.028"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.56.6.893"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.08.012"},{"key":"e_1_2_6_27_1","first-page":"286","article-title":"L'examen psychologique dans les cas d'encephalopathie traumatique","volume":"28","author":"Rey A","year":"1964","journal-title":"Archives de Psychologie"},{"key":"e_1_2_6_28_1","volume-title":"Wechsler Memory Scale\u2014Revised Manual","author":"Wechsler D","year":"1987"},{"key":"e_1_2_6_29_1","volume-title":"Boston Naming Test","author":"Kaplan E","year":"1983"},{"key":"e_1_2_6_30_1","volume-title":"A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary","author":"Strauss E","year":"2006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.2466\/pms.1958.8.3.271"},{"key":"e_1_2_6_32_1","volume-title":"Wechsler Adult Intelligence Scale\u2014Revised Manual","author":"Wechsler D","year":"1981"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/13854049208401877"},{"key":"e_1_2_6_34_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM\u2010IV)","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2004.03643.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318294b462"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-012-0926-4"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.06.015"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws373"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.06.062"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.685"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls256"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-015-0420-6"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.05.009"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.9.1048"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006338"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13524"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1519\/00139143-200932020-00002"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14670","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T18:19:39Z","timestamp":1762193979000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,21]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/jgs.14670"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14670","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,21]]}}}