{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:48:56Z","timestamp":1788407336154,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008479","name":"Claude Pepper Older Americans Independence Center, Wake Forest School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    The Systolic Blood Pressure Intervention Trial (\n                    <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n                    ; ClinicalTrials.gov,\n                    <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n                    01206062) was stopped early because of significantly lower risk of cardiovascular disease in participants randomized to a systolic blood pressure target of 120 mmHg (intensive) than in those randomized to 140 mmHg (standard). The cardiovascular outcome benefit was also identified in subjects aged 75 and older assigned to the intensive arm\u201434% lower than in the standard arm\u2014in addition to 33% lower all\u2010cause mortality at 3.14 years of follow\u2010up. These beneficial outcomes held in older participants characterized as frail or with impaired gait speed. This article addresses several questions that need to be considered in applying the\n                    <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n                    results to the clinical care of older adults: Why are the\n                    <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n                    results discordant from those of epidemiological studies? Do the\n                    <jats:styled-content style=\"fixed-case\">SPRINT<\/jats:styled-content>\n                    findings generalize to the frail, older adults that I care for? Were there more adverse events in the intensive treatment group? What about cognitive and kidney outcomes? What are future considerations, and how low should we go?\n                  <\/jats:p>","DOI":"10.1111\/jgs.14681","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T03:38:17Z","timestamp":1478489897000},"page":"16-21","source":"Crossref","is-referenced-by-count":27,"title":["Applying the Systolic Blood Pressure Intervention Trial Results to Older Adults"],"prefix":"10.1111","volume":"65","author":[{"given":"Mark A.","family":"Supiano","sequence":"first","affiliation":[{"name":"Division of Geriatrics School of Medicine University of Utah Salt Lake City Utah"},{"name":"Geriatric Research, Education, and Clinical Center Veterans Affairs Salt Lake City Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff D.","family":"Williamson","sequence":"additional","affiliation":[{"name":"Section on Geriatric Medicine Department of Internal Medicine School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.03.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04203.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.01.007"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3283577b05"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514537404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51565.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028631"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24530"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05513"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12100"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12803"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2010.00573.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001286"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv228"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.037"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801369"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0328-1"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11403-6"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540330050034"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d7541"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002290"}],"container-title":["Journal 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