{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:02:43Z","timestamp":1789390963353,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Brain\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      \u2010markers are risk factors of dementia and decline in cognition and daily functioning. It is unknown to what extent the associations of brain\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      \u2010markers with cognition and daily functioning are part of the pathway leading to dementia. We aimed to investigate associations of brain\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      \u2010markers with change in cognition and daily functioning during 15 years of follow\u2010up, including their relation to dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design, Setting, and Participants<\/jats:title>\n                    <jats:p>\n                      Four hundred and sixty three stroke\u2010free and non\u2010demented participants from the population\u2010based Rotterdam Study that underwent brain\u2010\n                      <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>\n                      , yielding brain volumetrics, between 1995 and 1996.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      We assessed cognition using the Mini\u2010Mental State Examination (\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      ) and daily functioning using instrumental and basic activities of daily living (\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BADL<\/jats:styled-content>\n                      ) up to seven times between 1990 and 2011. Analyses were performed both including and excluding incident demented participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Smaller brain volume associated with larger decline in\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      , and\n                      <jats:styled-content style=\"fixed-case\">BADL<\/jats:styled-content>\n                      . Larger white matter lesion volume associated with larger decline in\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      . Frontal lobe volume associated strongest with decline in\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BADL<\/jats:styled-content>\n                      , and temporal lobe volume with decline in\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      . After excluding incident demented participants (n = 63), associations with\n                      <jats:styled-content style=\"fixed-case\">IADL<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">BADL<\/jats:styled-content>\n                      remained, while associations with\n                      <jats:styled-content style=\"fixed-case\">MMSE<\/jats:styled-content>\n                      disappeared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Smaller brain volumes and larger white matter volume associate with larger decline in cognition and daily functioning, during 15 years of follow\u2010up. Importantly, the relation of brain volume with cognition, but not daily functioning, was driven by those individuals that ultimately developed dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14775","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T09:47:27Z","timestamp":1486374447000},"page":"1258-1266","source":"Crossref","is-referenced-by-count":17,"title":["Brain\n                    <scp>MRI<\/scp>\n                    \u2010markers Associate Differentially with Cognitive Versus Functional Decline Leading to Dementia"],"prefix":"10.1111","volume":"65","author":[{"given":"Vincentius J. A.","family":"Verlinden","sequence":"first","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Radiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos N.","family":"van der Geest","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hofman","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Epidemiology Harvard T.H. Chan School of Public Health Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiro J.","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Radiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Medical Informatics Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Faculty of Applied Sciences Delft University of Technology Delft The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aad","family":"van der Lugt","sequence":"additional","affiliation":[{"name":"Department of Radiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike W.","family":"Vernooij","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Radiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Radiology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"},{"name":"Department of Neurology Erasmus MC University Medical Centre Rotterdam Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp202"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13803395.2011.614598"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.04.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022066"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh553"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53214.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10294"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.06.037"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2477"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50608.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20630"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-1389"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0082-x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-011-9624-z"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.12.012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.05.018"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.1.57"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.609"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(197607)32:3<654::AID-JCLP2270320336>3.0.CO;2-Z"},{"key":"e_1_2_7_22_1","volume-title":"Neuropsychological Assessment","author":"Lezak MD","year":"2004"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(198805)44:3<403::AID-JCLP2270440315>3.0.CO;2-0"},{"key":"e_1_2_7_24_1","first-page":"789","article-title":"The dimensions of health outcomes: The health assessment questionnaire, disability and pain scales","volume":"9","author":"Fries JF","year":"1982","journal-title":"J Rheumatol"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01590.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182553be6"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700015889"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.149.6.698"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1359312"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12192"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-006-9002-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.08.001"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617707070853"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0238-4"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14775","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14775","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:32:48Z","timestamp":1762191168000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14775"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,6]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/jgs.14775"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14775","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,6]]}}}