{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:00:11Z","timestamp":1788199211011,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG22376"],"award-info":[{"award-number":["U01AG22376"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["T32AG019134"],"award-info":[{"award-number":["T32AG019134"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K07AG043587"],"award-info":[{"award-number":["K07AG043587"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["U01AG22376"],"award-info":[{"award-number":["U01AG22376"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008269","name":"Michigan Institute for Clinical and Health Research","doi-asserted-by":"publisher","award":["UL1TR000433"],"award-info":[{"award-number":["UL1TR000433"]}],"id":[{"id":"10.13039\/100008269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,6]]},"abstract":"\n Objectives<\/jats:title>\n \n To test whether structured physical activity (\n PA<\/jats:styled-content>\n ) is associated with a greater reduction in major mobility disability (\n MMD<\/jats:styled-content>\n ) in older persons with metabolic syndrome (MetS) than in those without.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n Data from the Lifestyle Interventions and Independence for Elders (\n LIFE<\/jats:styled-content>\n ) Study, a multicenter randomized trial of 1,635 persons with assessments every 6 months (average 2.7 years).\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Eight U.S. centers.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Sedentary men and women aged 70 to 89 with functional limitations (N = 1,535); 100 participants were excluded because of missing MetS data.<\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n \n Participants were randomized to a moderate\u2010intensity\n PA<\/jats:styled-content>\n program (n = 766) or a health education program (n = 769).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n MetS was defined according to the 2009 multiagency harmonized criteria. Outcomes included incident\n MMD<\/jats:styled-content>\n (loss of ability to walk 400 m) and persistent\n MMD<\/jats:styled-content>\n (two consecutive\n MMD<\/jats:styled-content>\n diagnoses or one\n MMD<\/jats:styled-content>\n diagnosis followed by death).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seven hundred sixty\u2010three (49.7%) participants met criteria for MetS.\n PA<\/jats:styled-content>\n reduced incident\n MMD<\/jats:styled-content>\n more than health education did in participants with MetS (hazard ratio (\n HR<\/jats:styled-content>\n ) = 0.72, 95% confidence interval (\n CI<\/jats:styled-content>\n ) = 0.57\u20130.91,\n P<\/jats:italic>\n = .007) but not in those without MetS (\n HR<\/jats:styled-content>\n = 0.96, 95%\n CI<\/jats:styled-content>\n = 0.73\u20131.25,\n P<\/jats:italic>\n = .75); the test for statistical interaction was not significant (\n P<\/jats:italic>\n = .13).\n PA<\/jats:styled-content>\n reduced the risk of persistent\n MMD<\/jats:styled-content>\n in participants with MetS (\n HR<\/jats:styled-content>\n = 0.57, 95%\n CI<\/jats:styled-content>\n = 0.41\u20130.79,\n P<\/jats:italic>\n < .001) but not in those without MetS (\n HR<\/jats:styled-content>\n = 0.97, 95%\n CI<\/jats:styled-content>\n = 0.67\u20131.41,\n P<\/jats:italic>\n = .87). The test for statistical interaction was significant (\n P<\/jats:italic>\n = .04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Moderate\u2010intensity\n PA<\/jats:styled-content>\n substantially reduces the risk of persistent\n MMD<\/jats:styled-content>\n in older persons with functional limitations with MetS but not in those without MetS. Comparable results were observed for incident\n MMD<\/jats:styled-content>\n . The\n LIFE PA<\/jats:styled-content>\n program may be an effective strategy for reducing mobility disability in vulnerable older persons with MetS.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14793","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T13:30:04Z","timestamp":1490707804000},"page":"1244-1250","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Metabolic Syndrome on the Mobility Benefit of a Structured Physical Activity Intervention\u2014The Lifestyle Interventions and Independence for Elders Randomized Clinical Trial"],"prefix":"10.1111","volume":"65","author":[{"given":"Anda","family":"Botoseneanu","sequence":"first","affiliation":[{"name":"Department of Health and Human Services University of Michigan Ann Arbor and Dearborn Michigan"},{"name":"Institute of Gerontology University of Michigan Ann Arbor and Dearborn Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Division of Public Health Sciences School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T.","family":"Ambrosius","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Division of Public Health Sciences School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather G.","family":"Allore","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Department of Internal Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Anton","sequence":"additional","affiliation":[{"name":"Institute on Aging Department of Aging and Geriatric Research University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara C.","family":"Folta","sequence":"additional","affiliation":[{"name":"Friedman School of Nutrition Science and Policy Tufts University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[{"name":"Department of Health Research and Policy Department of Medicine School of Medicine Stanford University Stanford California"},{"name":"Stanford Prevention Research Center Department of Medicine School of Medicine Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara J.","family":"Nicklas","sequence":"additional","affiliation":[{"name":"J. Paul Sticht Center on Aging School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie J.","family":"Spring","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa S.","family":"Strotmeyer","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Center for Aging and Population Health Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-0368","authenticated-orcid":false,"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Division of Geriatrics Department of Internal Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the LIFE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.192644"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-0407.2010.00078.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1795"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1195"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00607.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt101"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5616"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.522"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.317"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2004.02.044"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324597"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr123"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200107000-00010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi083"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt064"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000185659.11982.3d"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2011.03389.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.62"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls213"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp150"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1139\/h06-090"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008234"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.11.008"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12321"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.6.1277"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13152"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.5.823"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01339.x"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.17.2018"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14793","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14793","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:32:39Z","timestamp":1762191159000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,28]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/jgs.14793"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14793","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,28]]}}}