{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:31:26Z","timestamp":1791822686379,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T00:00:00Z","timestamp":1487635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["58\u20101950\u20100\u2010014"],"award-info":[{"award-number":["58\u20101950\u20100\u2010014"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K07AG3587"],"award-info":[{"award-number":["K07AG3587"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n Background<\/jats:title>\n \n Physical activity (\n PA<\/jats:styled-content>\n ) reduces the rate of mobility disability, compared with health education (\n HE<\/jats:styled-content>\n ), in at risk older adults. It is important to understand aspects of performance contributing to this benefit.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate intervention effects on tertiary physical performance outcomes.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n \n The Lifestyle Interventions and Independence for Elders (\n LIFE<\/jats:styled-content>\n ) was a multi\u2010centered, single\u2010blind randomized trial of older adults.\n <\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Eight field centers throughout the United States.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n 1635 adults aged 78.9 \u00b1 5.2 years, 67.2% women at risk for mobility disability (Short Physical Performance Battery [SPPB] <10).<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n \n Moderate\n PA<\/jats:styled-content>\n including walking, resistance and balance training compared with\n HE<\/jats:styled-content>\n consisting of topics relevant to older adults.\n <\/jats:p>\n <\/jats:sec>\n \n Outcomes<\/jats:title>\n \n Grip strength,\n SPPB<\/jats:styled-content>\n score and its components (balance, 4 m gait speed, and chair\u2010stands), as well as 400 m walking speed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Total\n SPPB<\/jats:styled-content>\n score was higher in\n PA<\/jats:styled-content>\n versus\n HE<\/jats:styled-content>\n across all follow\u2010up times (overall\n P<\/jats:italic>\n = .04) as was the chair\u2010stand component (overall\n P<\/jats:italic>\n < .001). No intervention effects were observed for balance (overall\n P<\/jats:italic>\n = .12), 4 m gait speed (overall\n P<\/jats:italic>\n = .78), or grip strength (overall\n P<\/jats:italic>\n = .62). However, 400 m walking speed was faster in\n PA<\/jats:styled-content>\n versus\n HE<\/jats:styled-content>\n group (overall\n P<\/jats:italic>\n =<.001). In separate models, 29% of the rate reduction of major mobility disability in the\n PA<\/jats:styled-content>\n versus\n HE<\/jats:styled-content>\n group was explained by change in\n SPPB<\/jats:styled-content>\n score, while 39% was explained by change in the chair stand component.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Lower extremity performance (\n SPPB<\/jats:styled-content>\n ) was significantly higher in the\n PA<\/jats:styled-content>\n compared with\n HE<\/jats:styled-content>\n group. Changes in chair\u2010stand score explained a considerable portion of the effect of\n PA<\/jats:styled-content>\n on the reduction of major mobility disability\u2013consistent with the idea that preserving muscle strength\/power may be important for the prevention of major mobility disability.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14804","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T12:34:35Z","timestamp":1487680475000},"page":"1427-1433","source":"Crossref","is-referenced-by-count":79,"title":["Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility"],"prefix":"10.1111","volume":"65","author":[{"given":"Adam J.","family":"Santanasto","sequence":"first","affiliation":[{"name":"Center for Aging and Population Health Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W.","family":"Glynn","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Lovato","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven N.","family":"Blair","sequence":"additional","affiliation":[{"name":"Arnold School of Public Health University of South Carolina Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Nutrition, Exercise Physiology, and Sarcopenia Laboratory Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-0368","authenticated-orcid":false,"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Medicine Yale School of Medicine New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M.","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health University of Maryland School of Medicine Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Chi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[{"name":"School of Medicine Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa S.","family":"Strotmeyer","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Manini","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research College of Medicine University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bret H.","family":"Goodpaster","sequence":"additional","affiliation":[{"name":"Translational Research Institute for Metabolism and Diabetes Florida Hospital Sanford Burnham Orlando Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research College of Medicine University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health Department of Epidemiology Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the LIFE Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53501.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/55.4.M221"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0204-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.6.558"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00260"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2389.2003.51267.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1989.03420180087036"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0749-3797(03)00179-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00392.2009"},{"key":"e_1_2_6_14_1","first-page":"CD002759","article-title":"Progressive resistance strength training for improving physical function in older adults","volume":"8","author":"Liu CJ","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2006.00701.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.8.860"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008234"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20256"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.11.1157"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1387-9"},{"key":"e_1_2_6_21_1","first-page":"CD004963","article-title":"Exercise for improving balance in older people","volume":"11","author":"Howe TE","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_22_1","first-page":"697","article-title":"The effects of strength and power training on single\u2010step balance recovery in older adults: A preliminary study","volume":"9","author":"Pamukoff DN","year":"2014","journal-title":"Clin Interv Aging"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S56682"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2318-13-105"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glr123"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.5616"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt064"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/49.2.M85"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503023320902"},{"key":"e_1_2_6_30_1","first-page":"314","article-title":"The Modified Mini\u2010Mental State (3MS) examination","volume":"48","author":"Teng EL","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_6_31_1","volume-title":"Borg's Perceived Exertion and Pain Scales","author":"Borg G","year":"1998"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200107000-00010"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0594.2008.00446.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.8.M539"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/env.2193"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.00530.x"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-014-0287-y"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90425.2008"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14804","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.14804","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:04:17Z","timestamp":1762200257000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,21]]},"references-count":37,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/jgs.14804"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14804","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,21]]}}}