{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T08:25:22Z","timestamp":1789979122648,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T00:00:00Z","timestamp":1491782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\n Objectives<\/jats:title>\n \n To compare the clinical characteristics of and use of oral anticoagulant (\n OAC<\/jats:styled-content>\n ) therapy in individuals aged 80 and older with atrial fibrillation (\n AF<\/jats:styled-content>\n ) with those of individuals younger than 80 with\n AF<\/jats:styled-content>\n in clinical practice.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Observational study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n \n The ReAl\u2010life Multicenter Survey Evaluating Stroke prevention strategies in Turkey trial (\n NCT<\/jats:styled-content>\n 02344901), a national observational registry.\n <\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Turkish adults with nonvalvular\n AF<\/jats:styled-content>\n (\n NVAF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Age data were collected at the time of entry into the registry and the octogenarian subgroup included all patients aged \u2265 80 years. We compared background and management in octogenarian with non\u2010octogenarian AF patients.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifty\u2010seven cardiology units enrolled 6,273 individuals in 3\u00a0months. Participants aged 80 and older (n\u00a0=\u00a01,170) were more likely to be female (60.7% vs 54.7%,\n P<\/jats:italic>\n \u00a0<\u00a0.001) and had a higher prevalence of persistant or permanent\n AF<\/jats:styled-content>\n , comorbidities, history of cerebral vascular accident, and major bleeding. As a consequence of having more comorbidities, Congestive heart failure; Hypertension; Aged 75 and older; Diabetes Mellitus; prior stroke, transient ischemic attack, or thromboembolism; Vascular disease; Aged 65 to 74; female Sex (\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n VAS<\/jats:styled-content>\n c) (4.32\u00a0\u00b1\u00a01.35 vs 3.04\u00a0\u00b1\u00a01.54,\n P<\/jats:italic>\n \u00a0<\u00a0.001) and Hypertension, Abnormal renal and liver function, Stroke, Bleeding, Labile international normalized ratio, Elderly, Drugs or alcohol (\n HAS<\/jats:styled-content>\n \u2010\n BLED<\/jats:styled-content>\n ) (2.14\u00a0\u00b1\u00a01.05 vs 1.54\u00a0\u00b1\u00a01.05,\n P<\/jats:italic>\n \u00a0<\u00a0.001) scores were higher in those aged 80 and older. The mean time in therapeutic range of individuals who were taking warfarin was lower in those aged 80 and older (45.9\u00a0\u00b1\u00a027.9) than in those younger than 80 (54.7\u00a0\u00b1\u00a024.9%,\n P<\/jats:italic>\n \u00a0<\u00a0.001). Anticoagulant therapy was prescribed for 74.8% of participants younger than 80% and 63% of those aged 80 and older (\n P<\/jats:italic>\n \u00a0<\u00a0.001). Higher\n CHA<\/jats:styled-content>\n 2<\/jats:sub>\n DS<\/jats:styled-content>\n 2<\/jats:sub>\n VAS<\/jats:styled-content>\n c score and lower\n HAS<\/jats:styled-content>\n \u2010\n BLED<\/jats:styled-content>\n score were independent predictors of\n OAC<\/jats:styled-content>\n prescription in participants aged 80 and older.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Nearly one\u2010fifth of individuals with\n NVAF<\/jats:styled-content>\n in this real\u2010world sample were aged 80 and older. Participants aged 80 and older were more likely to be female and have more comorbidities than those who were younger than 80. Those aged 80 and older with\n AF<\/jats:styled-content>\n were less likely to receive anticoagulants than those who were younger than 80, but having more comorbidities and other individual\u2010level characteristics may explain this difference. When they were prescribed\n OAC<\/jats:styled-content>\n s, participants aged 80 and older had poorer quality of anticoagulation than those who were younger, suggesting opportunities for improvement.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14855","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T11:16:17Z","timestamp":1491822977000},"page":"1684-1690","source":"Crossref","is-referenced-by-count":29,"title":["Real\u2010World Clinical Characteristics and Treatment Patterns of Individuals Aged 80 and Older with Nonvalvular Atrial Fibrillation: Results from the ReAl\u2010life Multicenter Survey Evaluating Stroke Study"],"prefix":"10.1111","volume":"65","author":[{"given":"Murat","family":"Biteker","sequence":"first","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Mugla Sitki Kocman University Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zcan","family":"Ba\u015faran","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Mugla Sitki Kocman University Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volkan","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Mugla Sitki Kocman University Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim","family":"Altun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Faculty of Medicine Mugla Sitki Kocman University Mugla Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"\u00d6zpamuk Karadeniz","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u015eanl\u0131urfa Bal\u0131kl\u0131g\u00f6l State Hospital \u015eanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet \u0130lker","family":"Tekkesin","sequence":"additional","affiliation":[{"name":"Department of Cardiology Siyami Ersek Heart Education and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"\u00c7ak\u0131ll\u0131","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tuzla State Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ceyhan","family":"T\u00fcrkkan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Siyami Ersek Heart Education and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Hamidi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Band\u0131rma State Hospital Band\u0131rma 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