{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:15:38Z","timestamp":1772496938317,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG21332"],"award-info":[{"award-number":["P30AG21332"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG12257"],"award-info":[{"award-number":["R01AG12257"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG18915"],"award-info":[{"award-number":["R01AG18915"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"University of Texas Southwestern Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,8]]},"abstract":"\n Objectives<\/jats:title>\n \n To systematically examine the relative magnitude and predictors of responses to exercise training in older adult with heart failure (\n HF<\/jats:styled-content>\n ) with reduced ejection fraction (\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n ), and preserved\n EF<\/jats:styled-content>\n (\n HF<\/jats:styled-content>\n p\n EF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Secondary analysis of a randomized controlled trial.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Outpatient cardiac rehabilitation program.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Individuals with HF (24 HFrEF, 24 HFpEF) who underwent supervised exercise training.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n The study included individual\u2010level data from the exercise training arms of a randomized controlled trial that evaluated the effect of 16\u00a0weeks of supervised moderate\u2010intensity endurance exercise training in older adults with chronic, stable\n HF<\/jats:styled-content>\n p\n EF<\/jats:styled-content>\n and\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n . Changes in peak oxygen uptake (\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n ) in response to supervised training in individuals with\n HF<\/jats:styled-content>\n p\n EF<\/jats:styled-content>\n were compared with that of individuals with\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n . The significant clinical predictors of changes in\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n with exercise training were assessed using univariate and multivariate regression models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Training\u2010related improvement in\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n was higher in participants with\n HF<\/jats:styled-content>\n p\n EF<\/jats:styled-content>\n than in those with\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n (change: 18.7\u00a0\u00b1\u00a017.6% vs \u22120.3\u00a0\u00b1\u00a015.4%,\n P<\/jats:italic>\n \u00a0<\u00a0.001). In univariate analysis, echocardiographic abnormalities in left ventricular structure and function and lower body mass index were associated with blunted response of\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n with exercise training. In multivariate regression analysis using stepwise selection, submaximal exercise systolic blood pressure, and resting early deceleration time were independent predictors of change in\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n The change in\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n in response to endurance exercise training in older adults with\n HF<\/jats:styled-content>\n differs\u00a0significantly according to\n HF<\/jats:styled-content>\n subtype, with greater\n V<\/jats:italic>\n O\n 2peak<\/jats:sub>\n improvement in\n HF<\/jats:styled-content>\n p\n EF<\/jats:styled-content>\n than\n HF<\/jats:styled-content>\n r\n EF<\/jats:styled-content>\n . These results suggest that the current Centers for Medicare and Medicaid Services policy excluding individuals with\n HF<\/jats:styled-content>\n p\n EF<\/jats:styled-content>\n from reimbursement from cardiac rehabilitation may need to be revisited.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14867","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T12:44:18Z","timestamp":1490359458000},"page":"1698-1704","source":"Crossref","is-referenced-by-count":55,"title":["Response to Endurance Exercise Training in Older Adults with Heart Failure with Preserved or Reduced Ejection Fraction"],"prefix":"10.1111","volume":"65","author":[{"given":"Ambarish","family":"Pandey","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalane W.","family":"Kitzman","sequence":"additional","affiliation":[{"name":"Section\u00a0of Cardiovascular Medicine School of Medicine Wake Forest University Winston\u2010Salem North Carolina"},{"name":"Sections of Geriatrics School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Brubaker","sequence":"additional","affiliation":[{"name":"Translational Science Center Wake Forest University Winston\u2010Salem North Carolina"},{"name":"Health and Exercise Science Department Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Haykowsky","sequence":"additional","affiliation":[{"name":"College of Nursing and Health Innovation University of Texas at Arlington Arlington Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Thomas","family":"Becton","sequence":"additional","affiliation":[{"name":"Section\u00a0of Cardiovascular Medicine School of Medicine Wake Forest University Winston\u2010Salem North Carolina"},{"name":"Sections of Geriatrics School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarett D.","family":"Berry","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Texas Southwestern Medical Center Dallas Texas"},{"name":"Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.131.suppl_2.o29"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1474"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0803563"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.17.2144"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00049.2015"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.01.010"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.963462"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.3.1003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-005-0116-2"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.5.2004"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181896c4e"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.110.958785"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.033"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02499.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(92)90094-4"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511023331806"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.08.062"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.113.000887"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.011031"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.454"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001615"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.08.015"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.11.062"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.659763"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2015.12.005"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.10.057"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313731"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14285-7"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001937"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.06.001"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.052"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14867","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14867","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T12:53:57Z","timestamp":1762174437000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,24]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jgs.14867"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14867","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,24]]}}}