{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:10:00Z","timestamp":1785190200788,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p>Prescribing medications, recognizing and managing medication side effects and drug interactions, and avoiding polypharmacy are all essential skills in the care of older adults in primary care. Important side effects of medications commonly prescribed in older adults (statins, proton pump inhibitors, trimethoprim\u2010sulfamethoxazole and fluoroquinolone antibiotics, zolpidem, nonsteroidal antiinflammatory drugs, selective serotonin reuptake inhibitors, dipeptidyl peptidase 4 inhibitors) were reviewed. Important drug interactions with four agents or classes (statins, warfarin, factor Xa inhibitors, and calcium channel blockers) are discussed.<\/jats:p>","DOI":"10.1111\/jgs.14870","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T11:17:15Z","timestamp":1490181435000},"page":"1578-1585","source":"Crossref","is-referenced-by-count":35,"title":["Common Drug Side Effects and Drug\u2010Drug Interactions in Elderly Adults in Primary Care"],"prefix":"10.1111","volume":"65","author":[{"given":"Susan E.","family":"Merel","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine Department of Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Paauw","sequence":"additional","affiliation":[{"name":"Division of General Internal Medicine Department of Medicine University of Washington Seattle Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13702"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7115.1096"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.8581"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-010-0120-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.10.118"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2014.02.023"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.153919"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.08.021"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc14-S014"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12414"},{"key":"e_1_2_6_12_1","unstructured":"FDA Drug Safety Communication: Important safety label changes to cholesterol\u2010lowering statin drugs. U.S. Food and Drug Administration [on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm293101.htmAccessed October 11 2016."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.15212"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14528"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.108"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01275.x"},{"key":"e_1_2_6_17_1","unstructured":"FDA Drug Safety Communication: Clostridium difficile\u2010associated diarrhea can be associated with stomach acid drugs known as Proton Pump Inhibitors (PPIs). U.S. Food and Drug Administration [on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm290510.htmAccessed October 11 2016."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e372"},{"key":"e_1_2_6_19_1","unstructured":"FDA Drug Safety Communication: Possible increased risk of fractures of the hip wrist and spine with the use of proton pump inhibitors[on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm213206.htmAccessed October 11 2016."},{"key":"e_1_2_6_20_1","unstructured":"FDA Drug Safety Communication\u2014Low magnesium levels can be associated with long\u2010term use[on\u2010line]. Available athttp:\/\/www.fda.gov\/Safety\/MedWatch\/SafetyInformation\/SafetyAlertsforHumanMedicalProducts\/ucm245275.htmAccessed October 11 2016."},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.04.027"},{"key":"e_1_2_6_22_1","first-page":"E166","article-title":"Proton pump inhibitors and the risk of acute kidney injury in older patients: A population\u2010based cohort study","volume":"3","author":"Antoniou T","year":"2015","journal-title":"Can Med Assoc J Open"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.7193"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-014-0554-0"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4791"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.142"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6196"},{"key":"e_1_2_6_28_1","unstructured":"FDA Drug Safety Communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection[on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm365050.htmAccessed October 12 2016."},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2014.970166"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010077"},{"key":"e_1_2_6_31_1","unstructured":"FDA Drug Safety Communication: FDA updates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects[on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm511530.htmAccessed October 12 2016."},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-015-0362-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g1996"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145271"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000809"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13807"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.004671"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60900-9"},{"key":"e_1_2_6_39_1","unstructured":"FDA Drug Safety Communication: FDA strengthens warning that Non\u2010Aspirin Nonsteroidal Anti\u2010Inflammatory Drugs (NSAIDs) can cause heart attacks or strokes[on\u2010line]. Available athttp:\/\/www.fda.gov\/drugs\/drugsafety\/ucm451800.htmAccessed October 12 2016"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1G293"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.2174\/15748863113089990036"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-014-2649-x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.07.010"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3503"},{"key":"e_1_2_6_45_1","unstructured":"FDA Drug Safety Communication: FDA warns that DPP\u20104 inhibitors for type 2 diabetes may cause severe joint pain[on\u2010line]. Available athttp:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm459579.htmAccessed October 19 2016."},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3510"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000456"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1497.2005.0136.x"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1345\/aph.1H418"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.10.011"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.06.012"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0561-1"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02579.x"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.282426"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jgs.14870","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:04:10Z","timestamp":1762200250000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/jgs.14870"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14870","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,21]]}}}