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Velocity (cm\/s) measured quantitatively during\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">WWT<\/jats:styled-content>\n                      conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 164 participants (34%) with polypharmacy of five or more medications were older (77.0 \u00b1 6.6 vs 76.0 \u00b1 6.4) and more likely to have hypertension, congestive heart failure, diabetes mellitus, myocardial infarction, and higher body mass index (\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      ) and to have fallen within the last year than the remaining 318 without polypharmacy and walked 6 cm\/s slower (\n                      <jats:italic>P<\/jats:italic>\n                      = .004) during\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      and 4 cm\/s slower during\n                      <jats:styled-content style=\"fixed-case\">WWT<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = .07), adjusting for age, sex, and education. Group differences were not statistically significant after adjusting for comorbidities. Prevalence of polypharmacy of eight or more medications was 10%. This group walked 11 cm\/s slower during\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      &lt; .001) and 8.6 cm\/s slower during\n                      <jats:styled-content style=\"fixed-case\">WWT<\/jats:styled-content>\n                      (\n                      <jats:italic>P<\/jats:italic>\n                      = .01) than those without polypharmacy, adjusted for age, sex, and education. Participants taking eight or more medications had slower\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      (8.5 cm\/s;\n                      <jats:italic>P<\/jats:italic>\n                      = .01), and\n                      <jats:styled-content style=\"fixed-case\">WWT<\/jats:styled-content>\n                      (6.9 cm\/s;\n                      <jats:italic>P<\/jats:italic>\n                      = .07), compared to those without polypharmacy, adjusting for comorbidities. Adjustments for\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      , high\u2010risk drugs, falls, and comorbidities yielded slower\n                      <jats:styled-content style=\"fixed-case\">NW<\/jats:styled-content>\n                      (9.4 cm\/s,\n                      <jats:italic>P<\/jats:italic>\n                      = .005) and\n                      <jats:styled-content style=\"fixed-case\">WWT<\/jats:styled-content>\n                      (7.9 cm\/s,\n                      <jats:italic>P<\/jats:italic>\n                      = .04 among those with polypharmacy compared to those without polypharmacy).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest an association between polypharmacy and locomotion that medical comorbidities only partly explained.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.14957","type":"journal-article","created":{"date-parts":[[2017,6,26]],"date-time":"2017-06-26T02:02:35Z","timestamp":1498442555000},"page":"2082-2087","source":"Crossref","is-referenced-by-count":52,"title":["Polypharmacy and Gait Performance in Community\u2013dwelling Older Adults"],"prefix":"10.1111","volume":"65","author":[{"given":"Claudene","family":"George","sequence":"first","affiliation":[{"name":"Division of Geriatrics Montefiore Medical Center Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[{"name":"Division of Cognitive and Motor Aging and Geriatrics Albert Einstein College of Medicine Bronx New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,26]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"431","volume-title":"Case\u2010Based Geriatrics: A Global Approach","author":"George CJ","year":"2011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.02.018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2013.827660"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2009.357"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20100018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04209.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02612.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355119"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-013-9570-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000172958.95282.2a"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2003.51455.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.03.022"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.03923.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glp033"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50415.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2008.06.004"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glv013"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-014-0029-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000119460"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2116"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.14957","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.14957","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:18:05Z","timestamp":1762186685000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.14957"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,26]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/jgs.14957"],"URL":"https:\/\/doi.org\/10.1111\/jgs.14957","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,26]]}}}