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Participants had low to moderate physical function, defined as self\u2010reported difficulty walking one\u2010quarter of a mile or climbing a flight of stairs and usual walk speed of less than 1 m\/s on a 4\u2010m usual\u2010pace walk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>\n                      Participants were randomized to losartan, omega\u20103 fish oil (\n                      <jats:italic>\u03c9<\/jats:italic>\n                      \u20103), combined losartan and\n                      <jats:italic>\u03c9<\/jats:italic>\n                      \u20103, or placebo. Randomization was stratified depending on eligibility for each group. A titration schedule was implemented to reach a dose that was safe and effective for\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106 reduction. Maximal doses were 100 mg\/d for losartan and 2.8 g\/d for\n                      <jats:italic>\u03c9<\/jats:italic>\n                      \u20103.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106, walking speed over 400 m, physical function (Short Physical Performance Battery), other inflammatory markers, safety, tolerability, frailty domains, and maximal leg strength were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results from the\n                      <jats:styled-content style=\"fixed-case\">ENRGISE<\/jats:styled-content>\n                      Pilot Study will provide recruitment yields, feasibility, medication tolerance and adherence, and preliminary data to help justify a sample size for a more definitive randomized trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:styled-content style=\"fixed-case\">ENRGISE<\/jats:styled-content>\n                      Pilot Study will inform a larger subsequent trial that is expected to have important clinical and public health implications for the growing population of older adults with low\u2010grade chronic inflammation and mobility limitations.\n                    <\/jats:p>\n                  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