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These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age\u2010related phenotypes, chronic diseases, geriatric syndromes, and loss of physiological resilience. Among the chronic conditions successfully treated by depleting senescent cells in preclinical studies are frailty, cardiac dysfunction, vascular hyporeactivity and calcification, diabetes mellitus, liver steatosis, osteoporosis, vertebral disk degeneration, pulmonary fibrosis, and radiation\u2010induced damage. Senolytic agents are being tested in proof\u2010of\u2010concept clinical trials. To do so, new clinical trial paradigms for testing senolytics and other agents that target fundamental aging mechanisms are being developed, because use of long\u2010term endpoints such as lifespan or healthspan is not feasible. These strategies include testing effects on multimorbidity, accelerated aging\u2010like conditions, diseases with localized accumulation of senescent cells, potentially fatal diseases associated with senescent cell accumulation, age\u2010related loss of physiological resilience, and frailty. If senolytics or other interventions that target fundamental aging processes prove to be effective and safe in clinical trials, they could transform geriatric medicine by enabling prevention or treatment of multiple diseases and functional deficits in parallel, instead of one at a time.<\/jats:p>","DOI":"10.1111\/jgs.14969","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T07:06:38Z","timestamp":1504508798000},"page":"2297-2301","source":"Crossref","is-referenced-by-count":516,"title":["The Clinical Potential of Senolytic Drugs"],"prefix":"10.1111","volume":"65","author":[{"given":"James L.","family":"Kirkland","sequence":"first","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Tchkonia","sequence":"additional","affiliation":[{"name":"Robert and Arlene Kogod Center on Aging Mayo Clinic Rochester 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