{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:25:09Z","timestamp":1787955909373,"version":"build-2784847793"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA\u201030 34944"],"award-info":[{"award-number":["CA\u201030 34944"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA\u201040360"],"award-info":[{"award-number":["CA\u201040360"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["CA\u2010097193"],"award-info":[{"award-number":["CA\u2010097193"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL\u201026490"],"award-info":[{"award-number":["HL\u201026490"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL\u201034595"],"award-info":[{"award-number":["HL\u201034595"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000909","name":"John A. Hartford Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000909","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n Background\/Objectives<\/jats:title>\n We sought to determine whether statin use for primary prevention is associated with a lower risk of cardiovascular events or mortality in older men.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Physicians\u2019 Health Study participants.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n 7,213 male physicians \u226570\u00a0years without a history of cardiovascular disease (\n CVD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n Multivariable propensity score for statin use with greedy matching (1:1) to minimize confounding by indication.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median baseline age was 77 (70\u2013102), median follow\u2010up was 7\u00a0years. Non\u2010users were matched to 1,130 statin users. Statin use was associated with an 18% lower risk of all\u2010cause mortality,\n HR<\/jats:styled-content>\n 0.82 (95%\n CI<\/jats:styled-content>\n 0.69\u20130.98) and non\u2010significant lower risk of\n CVD<\/jats:styled-content>\n events,\n HR<\/jats:styled-content>\n 0.86 (95%\n CI<\/jats:styled-content>\n 0.70\u20131.06) and stroke,\n HR<\/jats:styled-content>\n 0.70 (95%\n CI<\/jats:styled-content>\n 0.45\u20131.09). In subgroup analyses, results did not change according to age group at baseline (70\u201376 or >76\u00a0years) or functional status. There was a suggestion that those >76 at baseline did not benefit from statins for mortality,\n HR<\/jats:styled-content>\n 1.14 (95%\n CI<\/jats:styled-content>\n 0.89\u20131.47), compared to those 70\u201376 at baseline,\n HR<\/jats:styled-content>\n 0.83 (95%\n CI<\/jats:styled-content>\n 0.61\u20131.11); however the\n CI<\/jats:styled-content>\n s overlap between the two groups, suggesting no difference. Statin users with elevated total cholesterol had fewer major\n CVD<\/jats:styled-content>\n events than non\u2010users,\n HR<\/jats:styled-content>\n 0.68 (95%\n CI<\/jats:styled-content>\n 0.50\u20130.94) and\n HR<\/jats:styled-content>\n 1.43 (95%\n CI<\/jats:styled-content>\n 0.99\u20132.07)), respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Statin use was associated with a significant lower risk of mortality in older male physicians \u226570 and a nonsignificant lower risk of\n CVD<\/jats:styled-content>\n events. Results did not change in those who were >76\u00a0years at baseline or according to functional status. There was a suggestion that those with elevated total cholesterol may benefit. Further work is needed to determine which older individuals will benefit from statins as primary prevention.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.14993","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T11:40:39Z","timestamp":1505130039000},"page":"2362-2368","source":"Crossref","is-referenced-by-count":43,"title":["Statins for Primary Prevention of Cardiovascular Events and Mortality in Older Men"],"prefix":"10.1111","volume":"65","author":[{"given":"Ariela R.","family":"Orkaby","sequence":"first","affiliation":[{"name":"Geriatric Research, Education, and Clinical Center (GRECC) and Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) VA Boston Healthcare System Boston MA"},{"name":"Division of Aging Brigham and Women's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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