{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T09:41:18Z","timestamp":1775641278824,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Medicine and Division of Medical Education at the Washington University School of Medicine and Just-in-Time","award":["ID# CI044"],"award-info":[{"award-number":["ID# CI044"]}]},{"name":"Washington University Institute of Clinical and Translation Sciences","award":["UL1 TR000448"],"award-info":[{"award-number":["UL1 TR000448"]}]},{"name":"National Center for Advancing Translational Sciences of the National Institutes of Health (NIH)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,11]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine the effect of new oral anticoagulants (\n NOAC<\/jats:styled-content>\n s) on prescribing practices in older adults with atrial fibrillation (\n AF<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective observational cohort study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Academic medical center in St. Louis, Missouri.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Individuals aged 75 and older with\n AF<\/jats:styled-content>\n admitted to the hospital from October 2010 through September 2015 (N = 6,568, 50% female, 15% non\u2010white).\n <\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n Information on\n NOAC<\/jats:styled-content>\n s and warfarin prescribed at discharge was obtained from hospital discharge summaries, and linear regression was used to examine quarterly trends in their use. Multivariable logistic regression was used to assess independent predictors of anticoagulant use.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n NOAC<\/jats:styled-content>\n use increased over time (correlation coefficient (\n r<\/jats:italic>\n ) = 0.87,\n P<\/jats:italic>\n < .001), warfarin use did not change (\n r<\/jats:italic>\n = \u22120.16,\n P<\/jats:italic>\n = .50), and overall anticoagulant use (\n NOAC<\/jats:styled-content>\n s and warfarin) increased (\n r<\/jats:italic>\n = 0.68,\n P<\/jats:italic>\n = .001).\n NOAC<\/jats:styled-content>\n use increased over time in all age groups (75\u201379, 80\u201384, 85\u201389) except aged 90 and older, but increasing age attenuated the rate of\n NOAC<\/jats:styled-content>\n uptake. There was no consistent relationship between age and warfarin or overall anticoagulant use, except that individuals aged 90 and older had consistently lower use. Overall, fewer than 45% of participants were prescribed an anticoagulant. In multivariable analysis, younger age, white race, female sex, higher hemoglobin, higher creatinine clearance, being on a medical service, hypertension, stroke or transient ischemic attack, no history of intracranial hemorrhage, and a modified\n HAS<\/jats:styled-content>\n \u2010\n BLED<\/jats:styled-content>\n score of less than 3 increased the likelihood of receiving\n NOAC<\/jats:styled-content>\n s.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Prescription of anticoagulants for\n AF<\/jats:styled-content>\n increased in older adults primarily because of an increase in the use of\n NOAC<\/jats:styled-content>\n s. Nonetheless, fewer than 45% of participants were prescribed an anticoagulant. Additional research is needed to optimize prescribing practices for older adults with\n AF<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.15058","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T11:36:42Z","timestamp":1503315402000},"page":"2405-2412","source":"Crossref","is-referenced-by-count":33,"title":["Effect of New Oral Anticoagulants on Prescribing Practices for Atrial Fibrillation in Older Adults"],"prefix":"10.1111","volume":"65","author":[{"given":"Raymond B.","family":"Fohtung","sequence":"first","affiliation":[{"name":"Department of Medicine School of Medicine Washington University Saint Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Novak","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine Washington University Saint Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Medicine Washington University Saint Louis Missouri"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(93)90285-W"},{"key":"e_1_2_7_3_1","first-page":"54","article-title":"New oral anticoagulants for atrial fibrillation: Are they worth the risk?","volume":"39","author":"Shafeeq H","year":"2014","journal-title":"P T"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.19.2093"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.4.822"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200847050-00001"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.022"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.112.967299"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.05.044"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.05.013"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.09.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.09-1584"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-0134"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.22.2864"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309832"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.114.000907"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13200"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-014-1136-8"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14573"}],"container-title":["Journal of the American Geriatrics Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjgs.15058","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jgs.15058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T17:50:20Z","timestamp":1762192220000},"score":1,"resource":{"primary":{"URL":"https:\/\/agsjournals.onlinelibrary.wiley.com\/doi\/10.1111\/jgs.15058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jgs.15058"],"URL":"https:\/\/doi.org\/10.1111\/jgs.15058","archive":["Portico"],"relation":{},"ISSN":["0002-8614","1532-5415"],"issn-type":[{"value":"0002-8614","type":"print"},{"value":"1532-5415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]}}}