{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:59:16Z","timestamp":1764997156840,"version":"build-2065373602"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015\u20132531","521\u20132014\u201321\u201396"],"award-info":[{"award-number":["2015\u20132531","521\u20132014\u201321\u201396"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2014\u20131382"],"award-info":[{"award-number":["2014\u20131382"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      To explore the association between cardiovascular risk factor (\n                      <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n                      ) burden and limitation in walking speed, balance, and chair stand and to verify whether these associations vary according to age and cognitive status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Longitudinal population\u2010based study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Urban area of Stockholm, Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals aged 60 and older who participated in the Swedish National Study on Aging and Care in Kungsholmen and were free of limitations in walking speed (n\u00a0=\u00a01,441), balance (n\u00a0=\u00a01,154), or chair stands (n\u00a0=\u00a01,496) at baseline (2001\u201304).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      At baseline, data on demographic characteristics,\n                      <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n                      s, other lifestyle factors, C\u2010reactive protein, and cognitive function were collected.\n                      <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n                      burden was measured using the Framingham general cardiovascular risk score (\n                      <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>\n                      ). Limitations in walking speed (&lt;0.8\u00a0m\/s), balance (&lt;5\u00a0seconds), and chair stand (inability to rise 5 times) were determined at 3\u2010, 6\u2010, and 9\u2010year follow\u2010up. Data were analyzed using Cox proportional hazards models stratified according to age (&lt;78, \u226578).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During follow\u2010up, 326 persons developed limitations in walking speed, 303 in balance, and 374 in chair stands. An association between the\n                      <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>\n                      and walking speed limitation was evident only in adults younger than 78 (for each 1\u2010point increase in\n                      <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>\n                      : hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      )\u00a0=\u00a01.09, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a01.02\u20131.17) after controlling for potential confounders including cognitive function (correspondingly, in adults aged \u226578:\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a00.98, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a00.92\u20131.03). Also, higher\n                      <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>\n                      was significantly associated with faster decline in walking speed (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A higher\n                      <jats:styled-content style=\"fixed-case\">FRS<\/jats:styled-content>\n                      is associated with greater risk of subsequent development of walking speed limitation in adults younger than 78, independent of cognitive function. Interventions targeting multiple\n                      <jats:styled-content style=\"fixed-case\">CRF<\/jats:styled-content>\n                      s in younger\u2010old people may help in maintaining mobility function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15158","type":"journal-article","created":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T01:25:16Z","timestamp":1510277116000},"page":"2418-2424","source":"Crossref","is-referenced-by-count":27,"title":["Cardiovascular Risk Burden and Future Risk of Walking Speed Limitation in Older Adults"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-0093","authenticated-orcid":false,"given":"Emerald G.","family":"Heiland","sequence":"first","affiliation":[{"name":"Aging Research Center Department of Neurobiology Care Sciences and Society Karolinska Institutet\u2010Stockholm University Stockholm 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