{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T11:38:13Z","timestamp":1762169893117,"version":"build-2065373602"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T00:00:00Z","timestamp":1510358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG03949","1R01AG039409\u201301","R03 AG045474","1UL1TR001073","PO1 AG03949","2U01AG012535","5UL1TR001073\u201302"],"award-info":[{"award-number":["P01 AG03949","1R01AG039409\u201301","R03 AG045474","1UL1TR001073","PO1 AG03949","2U01AG012535","5UL1TR001073\u201302"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R37 NS 029993","R01 NS 40807","U10 NS 086528"],"award-info":[{"award-number":["R37 NS 029993","R01 NS 40807","U10 NS 086528"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","award":["R01 DE 13094"],"award-info":[{"award-number":["R01 DE 13094"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG039330","RO1AGO44007","AGO44829","R01AG036921"],"award-info":[{"award-number":["R01 AG039330","RO1AGO44007","AGO44829","R01AG036921"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2017,12]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine whether transcranial Doppler ultrasound (\n TCD<\/jats:styled-content>\n ) measures of mean blood flow velocity (\n MBFV<\/jats:styled-content>\n ) in the major cerebral arteries are associated with measures of lower extremity function in community\u2010dwelling older adults.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Cross\u2010sectional study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Community sample.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n Individuals aged 70 and older (mean 79.5, 54% female) without dementia participating in the Einstein Aging Study (N = 200).<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n All participants underwent\n TCD<\/jats:styled-content>\n assessments and tests of lower extremity function at an annual clinic visit. Average\n MBFV<\/jats:styled-content>\n for anterior (left and right anterior and middle cerebral arteries (\n MCA<\/jats:styled-content>\n s)) and posterior (vertebral (\n VA<\/jats:styled-content>\n ) and basilar (\n BA<\/jats:styled-content>\n ) artery) circulation was measured using a standardized\n TCD<\/jats:styled-content>\n protocol. Lower extremity function was characterized according to gait speed (cm\/s) measured using an instrumented walkway, balance according to unipedal stance time (\n UPST<\/jats:styled-content>\n , seconds), and lower extremity strength according to timed repeated chair rise (seconds).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Multiple regression models adjusted for age, sex, race, education, and medical comorbidities showed that lower\n MBFV<\/jats:styled-content>\n in the\n MCA<\/jats:styled-content>\n was associated with slower gait speed and chair rise time but not with\n UPST<\/jats:styled-content>\n . Ordinal regression models showed that lower\n MBFV<\/jats:styled-content>\n in the\n VA<\/jats:styled-content>\n and\n BA<\/jats:styled-content>\n is associated with shorter\n UPST<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Low\n MBFV<\/jats:styled-content>\n in the anterior and posterior cerebral circulation was associated with worse lower extremity function and balance in older adults. This might be indicative of the importance of age\u2010related changes in cerebral hemodynamics in the function of brain regions involved in specific aspects of physical performance.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.15181","type":"journal-article","created":{"date-parts":[[2017,11,11]],"date-time":"2017-11-11T08:52:40Z","timestamp":1510390360000},"page":"2659-2664","source":"Crossref","is-referenced-by-count":5,"title":["Transcranial Doppler and Lower Extremity Function in Older Adults: Einstein Aging Study"],"prefix":"10.1111","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1307-4589","authenticated-orcid":false,"given":"Ali","family":"Ezzati","sequence":"first","affiliation":[{"name":"Saul B. Korey Department of Neurology Albert Einstein College of Medicine Bronx New York"},{"name":"Department of Neurology Montefiore Medical Center Bronx New York"},{"name":"Departments of Neurology and Neurosurgery Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Department of Neurology Miller School of Medicine University of Miami Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Verghese","sequence":"additional","affiliation":[{"name":"Saul B. 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