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<jats:p>Randomized clinical trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Academic and private practices across the United States (N\u00a0=\u00a0102).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>\n                      Adults aged 50 and older with a systolic blood pressure (\n                      <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n                      ) of 130 to 180\u00a0mmHg at high risk of cardiovascular disease events, but without diabetes, history of stroke, symptomatic heart failure or ejection fraction less than 35%, dementia, or standing\n                      <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n                      less than 110\u00a0mmHg (N\u00a0=\u00a09,361).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>\n                      Treatment of\n                      <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n                      to a goal of less than 120\u00a0mmHg or 140\u00a0mmHg.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>\n                      Outcomes were\n                      <jats:styled-content style=\"fixed-case\">SAE<\/jats:styled-content>\n                      s involving syncope, hypotension, and falls. Predictors were treatment assignment, demographic characteristics, comorbidities, baseline measurements, and baseline use of cardiovascular medications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred seventy\u2010two (1.8%) participants had\n                      <jats:styled-content style=\"fixed-case\">SAE<\/jats:styled-content>\n                      s involving syncope, 155 (1.6%) hypotension, and 203 (2.2%) falls. Randomization to intensive\n                      <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n                      control was associated with greater risk of an\n                      <jats:styled-content style=\"fixed-case\">SAE<\/jats:styled-content>\n                      involving hypotension (hazard ratio (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      )\u00a0=\u00a01.67, 95% confidence interval (\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      )\u00a0=\u00a01.21\u20132.32,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002), and possibly syncope (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a01.32, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a00.98\u20131.79,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.07), but not falls (\n                      <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\n                      \u00a0=\u00a00.98, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      \u00a0=\u00a00.75\u20131.29,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.90). Risk of all three outcomes was higher for participants with chronic kidney disease or frailty. Older age was also associated with greater risk of syncope, hypotension, and falls, but there was no age\u2010by\u2010treatment interaction for any of the\n                      <jats:styled-content style=\"fixed-case\">SAE<\/jats:styled-content>\n                      outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Participants randomized to intensive\n                      <jats:styled-content style=\"fixed-case\">SBP<\/jats:styled-content>\n                      control had greater risk of hypotension and possibly syncope, but not falls. The greater risk of developing these events associated with intensive treatment did not vary according to age.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15236","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T09:49:23Z","timestamp":1522403363000},"page":"679-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Syncope, Hypotension, and Falls in the Treatment of Hypertension: Results from the Randomized Clinical Systolic Blood Pressure Intervention Trial"],"prefix":"10.1111","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-3856","authenticated-orcid":false,"given":"Kaycee M.","family":"Sink","sequence":"first","affiliation":[{"name":"Department of Medicine, Section on Department of Geriatric Medicine School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W.","family":"Evans","sequence":"additional","affiliation":[{"name":"Division of Public Health Sciences School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-4668","authenticated-orcid":false,"given":"Ronald I.","family":"Shorr","sequence":"additional","affiliation":[{"name":"Malcom Randall Veterans Affairs Medical Center Gainesville Florida"},{"name":"Department of Epidemiology University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey T.","family":"Bates","sequence":"additional","affiliation":[{"name":"Michael E. 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