{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T10:34:11Z","timestamp":1785321251334,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J American Geriatrics Society"],"published-print":{"date-parts":[[2018,3]]},"abstract":"\n Objectives<\/jats:title>\n \n To determine the effect of denosumab, which is used in primary osteoporosis (\n PO<\/jats:styled-content>\n ), in primary hyperparathyroidism (\n PHPT<\/jats:styled-content>\n )\u2010related osteoporosis.\n <\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Retrospective, longitudinal study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Outpatient osteoporosis clinic.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n \n Older women with\n PHPT<\/jats:styled-content>\n (78.6\u00a0\u00b1\u00a05.5) (n\u00a0=\u00a025) and\n PO<\/jats:styled-content>\n (78.8\u00a0\u00b1\u00a05.2) (n\u00a0=\u00a025) matched on age, body mass index, familial history of hip fracture, femoral bone mineral density (\n BMD<\/jats:styled-content>\n ), and personal history of fragility fractures.\n <\/jats:p>\n <\/jats:sec>\n \n Intervention<\/jats:title>\n Twenty\u2010four months of denosumab therapy.<\/jats:p>\n <\/jats:sec>\n \n Measurements<\/jats:title>\n \n We assessed the calcium\u2010phosphorus metabolism parameters;\n BMD<\/jats:styled-content>\n at the lumbar spine (\n LS<\/jats:styled-content>\n ), femoral neck (\n FN<\/jats:styled-content>\n ), and total hip (\n TH<\/jats:styled-content>\n ) using dual X\u2010ray absorptiometry; and morphometric vertebral fractures using radiographs in all subjects at baseline and after 24\u00a0months. Changes in\n BMD<\/jats:styled-content>\n and total alkaline phosphatase (\n ALP<\/jats:styled-content>\n ) activity were considered significant if they were greater than the least significant change (\n LS<\/jats:styled-content>\n 2.8%,\n FN<\/jats:styled-content>\n 5.9%,\n TH<\/jats:styled-content>\n 4.8%,\n ALP<\/jats:styled-content>\n \u201322%) and were expressed as percentage difference between end of follow\u2010up and baseline (\u0394).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n After 24\u00a0months, women with\n PHPT<\/jats:styled-content>\n had greater \u0394\n ALP<\/jats:styled-content>\n (\u221230.6\u00a0\u00b1\u00a011.3), \u0394\n FN<\/jats:styled-content>\n (5.6\u00a0\u00b1\u00a04.8), and \u0394\n TH<\/jats:styled-content>\n (4.8\u00a0\u00b1\u00a04.4) than those with\n PO<\/jats:styled-content>\n (\u0394\n ALP<\/jats:styled-content>\n \u221221.4\u00a0\u00b1\u00a013.1, \u0394\n FN<\/jats:styled-content>\n 2.9\u00a0\u00b1\u00a04.8, \u0394\n TH<\/jats:styled-content>\n 1.2\u00a0\u00b1\u00a04.1,\n P<\/jats:italic>\n \u00a0<\u00a0.05 for all comparisons). A significant increase in\n BMD<\/jats:styled-content>\n was more frequent in women with\n PHPT<\/jats:styled-content>\n (92%) than in those with\n PO<\/jats:styled-content>\n (52%,\n P<\/jats:italic>\n \u00a0<\u00a0.05) and it was 13.4 times as likely in women with\n PHPT<\/jats:styled-content>\n as in those with\n PO<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u00a0=\u00a0.02), regardless of possible confounders. Two subjects in each group had an incident fracture.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Denosumab therapy is effective in older women with\n PHPT<\/jats:styled-content>\n \u2010related osteoporosis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jgs.15250","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T11:22:48Z","timestamp":1516792968000},"page":"518-524","source":"Crossref","is-referenced-by-count":62,"title":["Protective Effect of Denosumab on Bone in Older Women with Primary Hyperparathyroidism"],"prefix":"10.1111","volume":"66","author":[{"given":"Cristina","family":"Eller\u2010Vainicher","sequence":"first","affiliation":[{"name":"Unit of Endocrinology Fondazione IRCCS C\u00e0 Granda\u2010Ospedale Maggiore Policlinico Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Community 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