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self\u2010reported mobility disability (SR\u2010MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Five longitudinal studies with older adults in different health states (onset of acute event, presence of chronic condition, sedentary, community living) were used to explore the relationship between gait speed and SR\u2010MD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Lifestyle Interventions and Independence for Elders Pilot (LIFE\u2010P), LIFE, Trial of Angiotensin\u2010Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN), Baltimore Hip Fracture Study (BHS2), Invecchiare in Chianti (InCHIANTI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Individuals aged 65 and older (N=3,540): sedentary, community dwelling (LIFE\u2010P\/LIFE), with hip fracture (BHS2), random population\u2010based sample (InCHIANTI), high cardiovascular risk (TRAIN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Usual\u2010pace gait speed across 3 to 4 m and SR\u2010MD, defined as inability to walk approximately 1 block or climb 1 flight of stairs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean gait speed of participants without SR\u2010MD was greater than 1.0 m\/s in InCHIANTI and TRAIN, 0.79 m\/s in LIFE\u2010P\/LIFE, and 0.46 m\/sec in BHS2. Of individuals with SR\u2010MD, mean gait speed was 0.08 m\/s slower in LIFE\u2010P\/LIFE, 0.19 m\/s slower in TRAIN, 0.22 m\/s slower in BHS2, and 0.36 m\/s slower in InCHIANTI. The optimal gait speed cutpoint for minimizing SR\u2010MD misclassification rates ranged from 0.3 m\/s in BHS2 to 1.0 m\/s in TRAIN. In longitudinal analyses, development of SR\u2010MD was dependent on initial gait speed and change in gait speed (p&lt;.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The relationship between absolute levels of gait speed and SR\u2010MD may be context specific, and there may be variations between populations. Across diverse clinical populations, clinical interpretations of how change in usual pace gait speed relates to development of SR\u2010MD depend on where on the gait speed continuum change occurs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jgs.15331","type":"journal-article","created":{"date-parts":[[2018,4,2]],"date-time":"2018-04-02T14:44:43Z","timestamp":1522680283000},"page":"954-961","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Gait Speed and Mobility Disability: Revisiting Meaningful Levels in Diverse Clinical Populations"],"prefix":"10.1111","volume":"66","author":[{"given":"Michael E.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Biostatistical Sciences, School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay","family":"Magaziner","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, School of Medicine University of Maryland Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony P.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Health and Exercise Science Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[{"name":"Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging Tufts University Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6450-0368","authenticated-orcid":false,"given":"Thomas M.","family":"Gill","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Geriatric Medicine, School of Medicine Yale University New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby C.","family":"King","sequence":"additional","affiliation":[{"name":"School of Medicine Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kritchevsky","sequence":"additional","affiliation":[{"name":"Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Sticht Center for Healthy Aging and Alzheimer's Prevention, School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Manini","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research, College of Medicine University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Medicine, Feinberg School of Medicine Northwestern University Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Neiberg","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences, School of Medicine Wake Forest University Winston\u2010Salem North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Orwig","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, School of Medicine University of Maryland Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Santanasto","sequence":"additional","affiliation":[{"name":"Center for Aging and Population Health, Department of Epidemiology, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[{"name":"Department of Aging and Geriatric Research, College of Medicine University of Florida Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Guralnik","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, School of Medicine University of Maryland Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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